Details
Category: Volume 08 Issue 02 February 2020
Hits: 997

Title: Clinical Profile and Neurodevelopmental Outcome of Neonatal Sepsis in a Tertiary Care Children Hospital from Eastern India

Authors: Dr Sreejata Mazumdar, Dr Suprit Basu, Dr Mala Bhattacharya

 DOI: https://dx.doi.org/10.18535/jmscr/v8i2.129

Abstract

   

Objective: Study the profile of neonatal sepsis, follow up the patients with neonatal sepsis in high risk clinic for 1year to assess neurodevelopmental and other physical morbidities & intervene the issues at earliest possibility.

Materials and Methods: Prospective, observational, longitudinal study done in high risk clinic for 1year in a tertiary care hospital of eastern India.

Result: Major (34.3%) causative organism of neonatal sepsis is Klebsiella.18.18% of total study population had neurodevelopmental delay. Growth failure, microcephaly, repeated hospital admission is more common in babies with neurodevelopmental delay. Persistent tone abnormality, abnormal electrophysiological are commonly associated with delayed neurodevelopment.

Conclusion: In our study we found that neurodevelopmental delay is common in neonatal sepsis. Regular follow up with appropriate screening test can identify it early & early stimulation can prevent or reduce developmental delay.

Keywords: Neonatal sepsis, neurodvelopmental outcome, follow up.

References

  1. Chaudhari S, Deo B. Neurodevelopmental assessment in the first year with emphasis on evolution of tone. Indian Pediatrics 2006;43:527-534.
  2. Mamatha P Samaga and B. Sumangala. Bacteriological profile of neonatal Septicaemia in MIMS, Mandya, India.J.Curr.Microbiol.App.Sci (2016) 5(3): 495-501
  3. Laving AM, Musoke RN, Wasunna AO, Revathi G. Neonatal bacterial meningitis at the new-born unit of Kenyatta national hospital. East Afr Med J. 2003 Sep;80(9):456-62.
  4. Tiskumara R, Fakharee SH, Liu CQ, Nuntnarumit P, Lui KM, Hammoud M, et al. Neonatal infections in Asia. Arch Dis Child Fetal Neonatal Ed. 2009 Mar;94(2):F144-8.
  5. Kumar GD, Ramachandran VG, Gupta P. Bacteriological analysis of blood culture isolates from neonates in a tertiary care hospital in India. J Health Popul Nutr 2002; 20(4):343-34
  6. Kayange N, Kamugisha E, Mwizamholya DL, Jeremiah S, Meshana SE. Predictors of positive blood culture and deaths among neonates with suspected neonatal sepsis in a tertiary hospital, Mwanza-Tanzania. BMC Pediatrics 2010; 10:39.
  7. Roy I, Jain A, Kumar M, Agarwal SK. Bacteriology of neo- natal septicemia in a tertiary care hospital of Northern In- dia. Indian Journal of Medical Microbiology 2002; 20 (3):156-159
  8. Bhagat R et al.Incidence of meningitis in ate onset sepsis. Int J Contemp Pediatr. 2015 May;2(2):96-102.
  9. Klinger G, Chin Cn, Beyene J, Perlman M. Predicting the outcome of neonatal bacterial meningitis. Pediatrics. 2000;106:477-482.
  10. Nitin S. Mehkarkar, P. S. Patil , Retrospective assessment neurodevelopmental outcome of neonatal meningitis. International Journal of Recent Trends in Science And Technology, ISSN 2277-2812 E-ISSN 2249-8109, Volume 7, Issue 3, 2013
  11. Stevens JP, Eames M, Kent A, Halket S, Holt D, Harvey. Long term outcome of neonatal meningitis. Arch Dis Child 2002;F179-F184.
  12. Amiel Tison C. A method for neurologic evaluation within the first year of life. Curr Prob Pediatr 1976; 7(1): 1-50
  13. Kubota T et al. Combination of neonatal ultrasonography and electroencephalography- sensitive means of early diagnosis of periventricular leucomalacia. Brain Dev 2002; 24: 698-702
  14. Chaudhari S et al. Transient tone abnormalities and cognitive outcome at five years. Indian Pediatr. Nov 17 2010; 47:931-935.
  15. Cerebral Palsy- Follow up of High Risk Neonates (Asia Pacific Childhood Disability Update 2005 ). Sarojini Budden MD, FRCP: Oregon Health and Sciences University and Pediatric Development Program Neonatal Follow up Clinic Legacy. Emanuel Children Hospital, Portland, Oregon. www.pediatriconcall.com/FORDOCT.
  16. Campos M et al. Comparison of post discharge growth in AGA and SGA infants. Ethnicity and Disease. Spring 2008; Vol. 18
  17. Mauren Hack et al. Differential effect of intrauterine and postnatal brain growth failure in infants of very low birth weight. Am J Dis Child 1989; 143(1): 63-68
  18. Bhagat R et al. Int J Contemp Pediatr. 2015 May;2(2):96-102
  19. Hussain N et al. The current incidence of ROP. Pediatrics 1999; Vol104, No. 3:e26.
  20. Doyle LW et al. Health and hospitalization after discharge in high risk infants. Semim Neonatol 2003 Apr 8(2): 137-145.

Corresponding Author

Dr Suprit Basu

Assistant Professor, Pediatric Medicine, Institute of Post Graduate and Medical Education Research, Kolkata, West Bengal