Title: Association of Anti - TPO Antibodies with Thyroid Dysfunction
Authors: Dr Sibi Chakravarthy.C, Dr M. K. Uthaya Sankar, Dr Hanush Raj, Dr Mythreini B.S
DOI: https://dx.doi.org/10.18535/jmscr/v8i2.125
Abstract
Introduction: Thyroid peroxidise (TPO) autoantibodies are a secondary response to thyroid injury and do not cause disease themselves. Though the presence of Anti TPO antibody may be a hallmark for autoimmune thyroid disease, there are reports that suggest the presence of Anti TPO antibodies can be a marker of thyroid dysfunction in future.
Objective: To assess the presence of Anti – TPO antibodies in patients with thyroid dysfunction.
Materials and Methods: This is a cross sectional study done on 60 Patients above the age of 18yrs attending General Medicine OPD with history of thyroid dysfunction and were subjected to thyroid function test and measurement of anti – TPO antibodies.
Results: Of the 60 patients 26 were found to be hypothyroidic, 15 were hyperthyroidic, FNAC of 7 patients suggested the presence of malignancy and 12 patients had Hashimoto’s thyroiditis. A significant association was found between Anti TPO levels and trends of anaemia with a p value of 0.02. On assessing the association between thyroid function test and Anti TPO antibody level, a significant relation with a p value of 0.01 was found with trends of free T3 levels. Of the 7 patients under malignancy group, 5 patients (71.4%) who had papillary carcinoma thyroid had elevated Anti TPO antibody levels.
Conclusion: In presence of Anti TPO antibodies along with a thyroid swelling a direct diagnosis of autoimmune thyroiditis should not be made and an FNAC biopsy should always be performed to rule out the likely possibility of carcinoma thyroid.
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