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Category: Volume 08 Issue 02 February 2020
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Title: A Comparative Study of Thyroid Profile, Lactate Dehydrogenase and Uric Acid in Cases of Normotensive versus Hypertensive Pregnant Women

Authors: Ramya Nemani, Kasibabu A

 DOI: https://dx.doi.org/10.18535/jmscr/v8i2.53

Abstract

Introduction: Hypertension during pregnancy is a major health problem. It is one of the leading causes of perinatal morbidity and mortality Keeping in view of the severity of this condition, the present study attempts to evaluate the serum levels of thyroid hormones reflecting hormonal changes and activity of serum lactate dehydrogenase, along with serum uric acid measurements in understanding the pathophysiological basis of this condition in cases of hypertensive pregnant women in comparison to normal pregnant women. 

Patients and Methods: 50 pre eclamptic women and 50 normotensive women are included in this study.

Results: Serum Thyroid stimulating hormone (TSH) levels areincreased, T3 and T4 levels are not significant serum LDH and Uric acid are increased in pre-eclampsia.

Conclusion: It is concluded that serum TSH, LDH and Uric acid are reliable and inexpensive markers to predict the severity and outcome of pre-eclampsia.

References

  1. Pregnancy hypertension in; Cunningham F, Lenovok, Blooms, Halh J, Giststrop L, Wenstram K, eds William obstetrics, 23rd edition, McGraw Hill, New York 2011; PP 706-728.
  2. Davrison J, Homuth V, Jeyabalan A, Conrad K, Kanumanchi A, Quaggin S et al. New aspects in the pathophysiology of preeclampsia. JAM SOC Nephrol 2004; 15:2440-2448.
  3. Kumar Ashok, Ghosh B K, Murthy N S. Maternal thyroid hormonal status in preeclampsia. Ind J Med Sci. 2005; 59 (2):57-63.
  4. Kharb S, Sardona D, Nanda S. Correlations of thyroid functions with severity and outcome of pregnancy. Ann Med Health Sci Res. 2013; 3:131-134.
  5. Qublan H S, Amarun V, Bateinan O, Al-Shradeih J, Tahat Y, Awamlah L et al; LDH as a biochemical marker of adverse pregnancy outcome in severe preeclampsia. Med Sci marit 2005; 11:393-397.
  6. Umasatyasri Y, Vani J, Sharita P. Role of LDH in preeclampsia-eclampsia as a prognostic marker. International Archives of Integrated medicine. 2015 September; 2 (9):88-93.
  7. Tziotis J, Puchner A M, Ulachas G et al. Renal glomerular and tubular function in relation to hyperuricemia of preeclampsia and eclampsia. Br J Obstat Gynaecol 2002; 109:197-201.
  8. Saleh F, Shukar-ud-din S, Boomro N, Serum Uric acid as predictor model for preeclampsia. Pak J Sung 2010; 26 (3): 246-251.
  9. Afroz R, Akhter QS, Sadia H, Sultana S. Serum lactate dehydrogenase levelin severe preeclampsia. J Bangladesh Soc Physiol. 2015; 10(2): 71-75.
  10. Bairwa R, Iqbal S. Serum lactate dehydrogenase (LDH) level in mild and severe preeclampsia as a prognostic marker. Int J Reprod Contracept Obstet Gynecol. 2018; 7(10): 3969-74.
  11. Satyanarayan AK, Chandregowda BH, Hemberal M, Taklikar RH. Maternal thyroid profile in preeclampsia. Int J Med Sci Public Health. 2015; 4: 1401-03.
  12. Sardana D, Nanda S, Kharb S. Thyroid hormones in pregnancy and preeclampsia. J Turk Ger Gynecol Assoc. 2009; 10 (3): 168-171.
  13. Harshavardhan L, Dariya SS, Sharma A, Verma L. Study of association of thyroid hormone in preeclampsia and normal pregnancy. J Assoc Physicians India. 2017; 65(11): 44-46.
  14. Tehrani FR, Pakniyat H, Naji A, Asefzadeh S. Thyroid hormone variations in preeclampsia. Journal of Qazvan University of Medical Sciences. 2003; 24: 18-23.
  15. Larijani B, Marsoosi V, Aghakhani S, Moradi A, Hashemipour S. Thyroid hormone alteration in preeclamptic women. Gynecol endocrine. 2004; 18: 97-100.
  16. Qublan H, Ammarin V, Bataineh O, et al. Lactic dehydrogenase as a biochemical marker of adverse pregnancy outcome in severe pre-eclampsia. Med Sci Monit. 2005; 11(8): 393-97.
  17. Kozic JR, Benton SJ, Hutcheson JA, et al. Abnormal liver function tests as predictors of adverse maternal outcomes in women with preeclampsia. J ObstetGynaecol Can. 2011; 33(10): 995-1004.
  18. Punthumapol C, Kittichotpanich B. Serumcalcium magnesium and uric acid in preeclampsia. J Med Assoc Thai. 2008; 91(7): 968-73.
  19. Bellomo G, Venanzi S, Saronio P, Verdura C, Narducci PL. Prognostic significance of serum uric acid in women with gestational hypertension. 2011; 58:704-08.

Corresponding Author

Ramya Nemani