Title: Serum Uric Level as a Marker of Myocardial Infarction

Authors: Dr Richa Giri, Dr Mohit Sachan, Dr Gaurav Chaudhary, Dr Shivendra Verma

 DOI: https://dx.doi.org/10.18535/jmscr/v8i2.45

Abstract

Background: Serum uric acid (SUA) is linked to various diseases but its association with the myocardial infarction(MI) has led physician to find whether  it can be used in diagnosing MI ,this  study was to assess and find clinical  value of SUA in MI.

Methods: This prospective study was studied in patients of MI willing to give informed consents and was diagnosed on the basis clinical history electrocardiography, troponin I level from august 2017 to September 2019.The relationship between troponin I level and SUA were analysed. All data were analysed using SPSS version 17 software for independent student t test and Pearson’s correlation coefficient analysis.

Results: The mean age of the patient who took part in the study was 57.31±12.016 years and for the control group was48.99±13.39 years

For Myocardial group mean value of serum uric acid (mg/dl) is 6.6±1.6 vs.3.9±0.31 in control group( p value is <0.001)

The mean serum uric acid in NSTEMI (6.77± 1.70mg/dl) was higher than STEMI (6.52± 1.57mg/dl) but difference was not statistically significant (p=0.628).

Conclusion: SUA is significantly raised in MI patients and is positively correlated with Troponin level.

References

 1 Abhishek goyal etal(2017)changes in the prevalence and social distribution of  cardiovascular disease and risk factors in India in volume 9,eo10947.

2 Mehrpooya M et al (2017). Study of Serum Uric Acid Levels in Myocardial Infarction and Its Association With Killip Class Acta Med Iran. 2017 Feb;55(2):97-102.

3 Suyoung Jang et al 2014. CLINICAL IMPACT OF SERUM URIC ACID IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION Journal of the American College of Cardiology Volume 63, Issue 12 Supplement, April 2014DOI: 10.1016/S0735-1097(14)60239-4

  1. Baker JF et al (2005) CLINICAL IMPACT OF SERUM URIC ACID IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION Am J Med.2005 Aug;118(8):816-26.
  2. Padma V et al.( 2017 ) Serum uric acid levels in acute myocardial infarction Int J Adv Med. 2017 Aug; 4(4):1010-1013
  3. Nadkar MY1, Jain VI. Serum uric acid in acute myocardial infarction. (2008)J Assoc Physicians India.2008 Oct;56:759-62
  4. Michiel J. Bos, et al (2006) Uric Acid Is a Risk Factor for Myocardial Infarction and Stroke The Rotterdam Study (Stroke. 2006;37:1503-1507.)
  5. Ravella Keerthika Chowdary et al (2016) Prognostic value of serum uric acid level in patients with acute myocardial infarctionCurr Res Cardiol 2016;3(3):63-66.
  6. Burki, L. et al (2013) Annals of King Edward Medical University (Print); ISSN 2079-7192; v. 19(3); p. 243-249
  7. Suresh Kumar Behera, Akshaya Kumar Samal (2018) Study of serum uric acid level as a prognostic marker in acute ST elevation myocardial infarction patients DOI: http://dx.doi.org/10.18203/2349-3933.ijam 20182108
  8. Kaushik Biswas et al(2016) A study on prognostic significance of serum uric acid in acute myocardial infarction in a tertiary care institute DOI: http:// dx.doi.org/10.18203/2320-6012.ijrms20163329
  9. Sunao Kojima et al (2005) Prognostic Usefulness of Serum Uric Acid After Acute Myocardial Infarction (The Japanese Acute Coronary Syndrome Study) DOI: https:// doi.org/10.1016/j.amjcard.2005.04.007
  10. Srikanth (2017) Crp And Uric Acid Levels As a prognostic Markers In Acute Myocardial Infarction IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 16, Issue 3 Ver. II (March.2017), PP 14-20 www.iosrjournals.org DOI: 10.9790/0853-1603021420www.iosrjournals.org 14| Page
  11. Vladimir Trkulja (2011) On-admission serum uric acid predicts outcomes after acute myocardial infarction: systematic review and meta-analysis of prognostic studies CLINICAL SCIENCE doi: 10.3325/cmj.2012.53. 162 www.cmj.hr

Corresponding Author

Dr Gaurav Chaudhary

Resident in KPS Institute of General Medicine GSVM Kanpur