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Category: Volume 08 Issue 02 February 2020
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Title: Study of Incidence of Malignancy in Upper Gastrointestinal tract in Dyspeptic Patients

Authors: Dr Pankaj K Patel, Dr Manoj Kumar, Dr Vivek Kumar Pandey

 DOI: https://dx.doi.org/10.18535/jmscr/v8i2.21

Abstract

Objective: The aim of study was to evaluate the results obtained by histopathological examination of biopsy material of dyspeptic patients who had undergone endoscopy. A correlation with causative agents and various risk factors with the results of histopathological examination was done.

Material and Methods: A total 600 dyspeptic patients were studied and among them 26 cases with malignancy have been included in the present study. Biopsy materials of the present study were collected from Sri Krishna Medical college, Muzaffarpur. Selection of cases for study in the present work was done by taking detailed history and clinical examination of patient suffering from dyspepsia. Prior to endoscopic biopsy all the relevant routine investigations (CBC, ESR, LFT, KFT, BT, CT, Blood sugar and Viral markers) were perfomed. Upper GIT endoscopy was done in selected patients suffering from dyspepsia and suspected biopsy material was taken out and kept in fixative(10 % formal saline).Tissue was processed and stained by H & E stain for histopathological examination.

Result: Malignacy in dyspeptic patient was more in male than female and more common in those whose staple food was rice (46.15 %). Adenocarcinoma of stomach was most common malignancy (92.3 %) followed by squamous cell carcinoma of oesophagus (7.69 %).

Conclusion:  The present study has pointed out important epidemiological contribution in the incidence of upper GIT malignancy in dyspeptic patients.

Keyword:  Dyspepsia, endoscopic biopsy, upper GIT malignancy.

References

  1. Cohen et al : Quoted by Ahuja & Chandra (1973), Amer. J. Dig. Dis., 16:815.1971.
  2. Costello et al: Brit. J. Surg; 64:47-51, 1977.
  3. Illingworth Dick : A text book of surgery. Path., 12th E.L.B.S. and Churchill, Livingstone, 1967.
  4. Julkunen : Scand. J. Gastroneterology, Jun. 30(6); 519-23, 1995
  5. Koteshwar Rao & Salasundaram et al : Ind.J. of Cancer 20 : 1-4, 1984.
  6. Kang : J. Gastroenterohepatology, Mar-Apr. 9(2), 1994
  7. Khodaskar M.B., Mahajan et al : Ind. J. of cancer 19: 23-240, 1982.
  8. Lee MG , West Indian Med J. 2004.
  9. Mayer RJ : Gastric Carcinoma N Engl. J. Med. 333:32, 1995.
  10. Mohan Das K.M. et al: Ind. Gastroenterol, 19:74-78, 2000
  11. Nagraj Rao D, Balasubramaniam Ganesh et al : Ind. J. Cancer 99, 727-731, 2002.
  12. Neuget Al et al : Epidemiology of Gastric Cancer; Semin. Oncol 23 : 281, 1996.
  13. Paymaster & P. Gangadharan : Cancer 21: 279-288, 1968
  14. Peterson: Ned. Tijdschr. Geneeskd. Feb 17; 134(7); 319-20, 1990.
  15. Phospha Krishna: Paper from Dept. of Surg. Faculty of Med. Siriraj Hospital Dhonburi (Thailand).National Science Congress, 1965.   
  16. Prabhakar, Tung & Sood: Ind. J. Surg. May 343-346, 1981
  17. Rao DN et al : Int. J. Cancer, 2002 June 10 ; 99(5): 727-31
  18. Remine W.H.: Am. J. Surg., 117: 177-184, 1969
  19. Segi et al : Gann 48 (Suppl.), 1-63, 1957
  20. Subharwal et al: J. Ind. MA; 64: 57-60, 1975.

Corresponding Author

Dr Manoj Kumar

Professor and H.O.D., Department of Pathology, S. K. Medical College, Muzaffarpur, India