Details
Category: Volume 08 Issue 02 February 2020
Hits: 1079

Title: Study of serum uric acid in Type 2 diabetes mellitus

Authors: Dr Uddhav Khaire, Dr Rahul Rathod, Dr Pramod Wattamwar

 DOI: https://dx.doi.org/10.18535/jmscr/v8i2.11

Abstract

Diabetes Mellitus (DM) is a metabolic disorder characterized by the presence of chronic hyperglycemia associated with impairment in the metabolism of carbohydrates, lipids and proteins. Uric acid is the end product of purine catabolism. Excessive serum uric acid accumulation can cause various diseases. For more than 50 years, increased serum levels of uric acid have been implicated in cardiovascular disease. Different mechanisms have been suggested through which uric acid may be involved in the atherosclerotic process and its clinical complications. Uric acid may act as a pro-oxidant, particularly at increased concentrations, and may be a marker of oxidative stress. The Morbidity and mortality due to non-communicable diseases specially attributed to diabetes mellitus and coronary heart disease is rising rapidly in India, causing nearly 5.8 million deaths per year annually. Considering the strong association between the levels of serum uric acid and the occurrence of coronary atherosclerosis in subjects with type 2 diabetes mellitus, the current study has been undertaken to assess the factors influencing the serum uric acid levels in patients with type 2 diabetes mellitus.

Objectives: To find out association between serum uric acid level and type 2 Diabetes Mellitus. Also correlate serum uric acid level to duration of type 2 Diabetes Mellitus.

Materials and Methods: This was a Case control study comparing between two groups of age and sex matched population.

Results: The mean serum uric acid level of diabetes mellitus of cases 5.10 and that of controls is 3.73 and the p value is 0.04 which is statistically significant. It shows that as duration of DM increases there is significant rise in Serum Uric acid level

Conclusion: Also there is a significant positive correlation between the levels of serum uric acid duration of DM and comorbidities in type 2 DM.

References

  1. Ahmed AM (2002) History of diabetes mellitus. Saudi Med J 23: 373- 378.
  2. Diabetes mellitus history- from ancient to modern times.
  3. Patlak M (2002) New weapons to combat an ancient disease: treating diabetes. FASEBJ 16: 1853
  4. Maitra A, Abbas AK (2005) Endocrine system. Robbins and Cotran Pathologic basis of disease (7thedtn). Saunders, Philadelphia. 1156-1226.
  5. Chen L, Magliano DJ, Zimmet PZ (2014) The worldwide epidemiology of type 2 diabetic mellitus mellitus: present and future perspectives. Nature reviews endocrinology
  6. Ramachandran A, Snehalatha C, Shetty AS, et al.Trends in prevalence of diabetes in Asian countries.World J Diabetes. 2012;3(6):110-7. doi:10.4239/wjd.v3.i6.110.
  7. Gupta R, Misra A. Type 2 diabetic mellitus in India: Regional disparities. Br J DiabetesVasc Dis. 2007;7:12-6. 6.
  8. Joshi SR, Das AK, Vijay VJ, et al. Challenges in diabetes care in India: sheer numbers, lack of awareness and inadequate control. J Assoc Physicians India. 2008;56:443-50.
  9. Thankappan KR, Shah B, Mathur P, et al. Risk factor profile for chronic non-communicable diseases: results of a community-based study in Kerala, India.Indian J Med Res. 2010;131:53-63
  10. K Park et al. Diabetes mellitus, in park`s text book of preventive and the social medicine, 20 ed. Jabalpur, M/s Banarasidas Bhanos publication, 2009, pp 341-345.
  11. Richard J. Johnson et.al., Is there pathogenic role for uric acid in hypertension and cardiovascular and renal disease?, Hypertension, 2009; 41: 1183-1190.
  12. Elizabeth T. Rosolowskyet.al., High normal Serum uric acid is associated with Impaired glomerular filtration Rate in Non-protein uric patients with Type I diabetes. Clin J Am Soc Nephrol, 2008; 3: 706-713.
  13. Carmine Zoccali et.al., Uric acid and endothelial dysfunction in essential hypertension, J Am Soc Nephrol, 2006;17: 1466-1471.
  14. Carmine Zoccali et.al., Uric acid and endothelial dysfunction in essential hypertension, J Am SocNephrol, 2006;17 : 1466-1471.
  15. Seppo Lehto et.al. Serum uric acid is a strong predictor of stroke in patient with Non-Insulin dependent Diabetes mellitus, Stroke, 1998; 29: 635-639.
  16. Saijo Y. et.al., Relationships of C-reactive protein, uric acid and glomerular filtration rate to arterial stiffness In Japanese subjects, Journal of human hypertension, 2005; 17: S165-S168.
  17. Chizyński K, Rózycka M., [Is hyperuricemia a cardiovascular risk factor?], WiadLek. 2006;59(5-6):364-7.
  18. Srivastava TR, Dixit RK. Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetic mellitus mellitus-a case control study. Natl J Physiol Pharm Pharmacol. 2017;7(2):170-3.
  19. Kushiyama A, Tanaka K, Hara S, Kawazu S. Linking uric acid metabolism to diabetic complications. World J Diabetes. 2014; 5(6):787–795. doi:10.4239/wjd.v5.i6.787
  20. Rao TM, Vanukuri NK. A study on serum uric acid levels in Type 2 diabetic mellitus mellitus and its association with cardiovascular risk factors. Int Arch Integr Med. 2016;3(12):148-55.
  21. Kushiyama A, Tanaka K, Hara S, Kawazu S. Linking uric acid metabolism to diabetic complications. World J Diabetes. 2014; 5(6):787–795. doi:10.4239/wjd.v5.i6.787.

Corresponding Author

Dr Pramod Wattamwar

MD Medicine, Junior Resident, Department of General medicine, Government Medical College and Hospital, Aurangabad, India