Details
Category: Volume 07 Issue 11 November 2019
Hits: 1212

Title: A Review on the CNS Activity of Pyrazolines

Authors: Swathi V, Shine Sudev, Dhanya K, Anju Jose, Sreelakshmi

 DOI: https://dx.doi.org/10.18535/jmscr/v7i11.107

Abstract

The five membered heterocyclic compound pyrazoline is a significant group in heterocyclic chemistry. Many pyrazoline compounds are found possess broad spectrum of biological activities. They are found to possess anti convulsant, neuroprotective, antidepressant, anti inflammatory, anticancer, antimicrobial activities etc. Various pyrazoline derivatives were synthesized and their CNS activities were studied In this review various CNS activities of pyrazolines were discussed. The results shows that pyrazolines and it’s derivatives found to possess CNS activity.

Keywords: Pyrazolines, CNS activity, molecular docking, antidepressant.

References

  1. N1-benzenesulfonyl-2-pyrazoline hybrids in neurological disorders: Synthesis, biological screening and computational studies, Avinash C. Tripathi,1Savita Upadhyay,1 Sarvesh Paliwal,2 and Shailendra K. Saraf*, 2018 Jan 19. 2018; 17: 126–148.
  2. Biological Activities of Pyrazoline Derivatives -A Recent Development Suresh Kumar*,1, Sandhya Bawa 1 , Sushma Drabu 1 , Rajiv Kumar1 and Himanshu Gupta2,* 1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, 2 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India Received: April 25, 2009; Accepted: May 20, 2009; Revised: May 21, 2009
  3. Synthesis and antidepressant activities of some 3,5-diphenyl-2-pyrazolines Erhan Palaskaa, Mutlu Aytemira , I. Tayfun Uzbayb , Dilek Erola,* a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey b Department of Pharmacology, Military Medicinal Academy of Gu¨lhane, Ankara, Turkey, European journal of medicinal chemistry, ISSN: 0223-5234, Vol: 36, Issue: 6, 2001,Page: 539-43
  4. Design, synthesis, and neuroprotective effects of series of pyrazolines against 6-hydroxy dopamine induced oxidative stress, Mehlika Dilek, Miris Dikmen, ozdemir, Belgin Sever,  Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress,   2018 Aug 27
  5. Synthesis, ADME prediction, molecular docking and in vivo biological evaluation, 2-pyrazoline derivatives in neuropharmacology: Savita Upadhyay, Avinash C,  Sarvesh Paliwal, and Shailendra K. Saraf*, 2017 May 8
  1. Pharmaceutical Importance of Pyrazoline Derivatives: A Mini Review Bayu Ardiansah* Department of Chemistry, FMIPA, Universitas Indonesia, Depok, 16424, Indonesia, journal f pharmaceutical science and researches
  2. Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease,  Oya Unsal-Tan,   Tuba Tuylu Kucukkilinc,  Beyza Ayazgök,  Ayla Balkan  and Keriman Ozadali-Sari  Med Chem Comm, 8 nov 2019
  1. Anticonvulsant evaluation of 2-pyrazolines carrying naphthyl moiety: An insight into synthesis and molecular docking study Birjees Nusrat, Nadeem Siddiqui, Meeta Sahu, Mohd. Javed Naim, Mohammad Shahar Yar, Ruhi Ali, Alam Ozair, Department of Pharmaceutical Chemistry, Faculty of Pharmacy Jamia Hamdard, Hamdard Nagar, New Delhi, India J. Pharm. Sci. vol.55  Sao Paulo  2019 Epub Aug 12, 2019
  2. Synthesis, preclinical evaluation and antidepressant activity of 5-subtituted phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamides, jerad Suresh, Bijo Mathew, S. Anbazhagan, 2014, 29 Apr2014, 437-445.
  3. Bicyclic pyrazolines, potential central nervous system depressants and antiinflammatory agentsjohn krapcho, Chester F. TurK, J. Med. Chem. 1979, 22, 2, 207-210, February 1, 1979
  4. Synthesis and antidepressant activities of some 3,5-diphenyl-2-pyrazolines, ,Mutlu Aytemir, Tayfun Ubay, Dilek Erol European journal of medicinal chemistry, volume 36, issue 6, june 2001, 539-543
  1. Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(200-hydroxy naphthalen-100-yl)-1,5-diphenyl-2-pyrazolines Y. Rajendra Prasad,* A. Lakshmana Rao, L. Prasoona, K. Murali and P. Ravi Kumar University College of Pharmaceutical Sciences, Andhra University, Visakapatnam 530003, Andhra Pradesh, India , 25 April 2005
  2. Pyrazoline Derivatives: A Worthy Insight into the Recent Advances and Potential Pharmacological Activities Md. Azizur Rahman1*, Anees A. Siddiqui, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Integral University, Lucknow (Uttar Pradesh 226026, India, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi International journal of pharmaceutical sciences and drug Research, 2010, 165-175
  3. Palaska E, Aytemir M, Uzbay IT, Erol D. Synthesis and antidepressant activities of some 3,5-diphenyl-2- pyrazolines. Eur J Med Chem 2001;36:539-43 65. Prasad YR, Rao AL, Prasoona L, et al.
  4. Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2’’-hydroxynaphthalen-1’’-yl)-1,5- diphenyl-2-pyrazolines. Bioorg Med Chem Lett 2005;15:5030-4
  5. Synthesis and anticonvulsant activity of some 2-pyrazolines derived from chalcones, Nagihan Beyhan, Salih Gumbru, Feyza Aricoglu, Arabian Journal of chemistry, Volume 10, may2017, page S2073-81
  6. A Review On Recent Development of Pyrazoline As A Pharmocologically Active Molecule Rubina Bhutani*1, Dharam Pal Pathak 1, Asif Husain 2, Garima Kapoor 1 And Ravi Kant, Delhi Institute Of Pharmaceutical Sciences And Research1, New Delhi, India, Department of Pharmaceutical Chemistry 2, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) New Delhi, India International Journal of Pharmaceutical Sciences And Research, 2018.

Corresponding Author

Swathi V

Department of Pharmaceutical Chemistry, Moulana College of Pharmacy, Angadipuram, Perinthalmanna, Malappuram, Kerala, India