Title: A Prospective Study of Dexmedetomidine to Attenuate Haemodynamic Responses to Endotracheal Intubation
Authors: Dr Md. Arshad Imam, Dr Md. Shariq Sayeed
DOI: https://dx.doi.org/10.18535/jmscr/v7i10.162
Abstract
Introduction
Since the time of inception of endotracheal anesthesia in the last quarter of 19th century, endotracheal intubation has become one of the very common procedures performed in the practice of anesthesia. We have a novel drug from the family of alpha-2 adrenergic agonist, Dexmedetomidine, which is a D-isomer of medetomidine. It is more specific for alpha-2 adrenergic receptor and shorter acting than clonidine. In recent study this drug has been shown to have clinically significant effects on anesthetic requirements, hemodynamic responses induced by anesthesia and surgery in patients. This study is an attempt to assess the safety and efficacy of dexmedetomidine in attenuating hemodynamic responses to laryngoscopy and endotracheal intubation.
References
- Derbishire DR, Chmeilewski A, Feli D, Vater M, Achola K and Smith G. plasma catecholamine responses to tracheal intubation. Br J anesthesia 1983;55[9] :855-860
- Singh O. circulatory response to endotracheal intubation in hypertensive patients. Ind J anesthesia 1999;37[1]:4-7.
- Reddy SV, Balaji D, Ahmed SN. Dexmedetomidine versus esmolol to attenuate the hemodynamic response to laryngoscopy and tracheal intubation: A randomized double-blind clinical study. Int J App Basic Med Res. 2014;4:95-100.
- Williams P, Waewick R. Gray’s anatomy. 27th Edinburgh, Churchill Livingstone,1989;1249-1259.
- Sulaiman S, Vakamudi M and Gandham R. the effects od dexmedetomidine on attenuation of stress response to endotracheal intubation in patients undergoing elective off pump coronary artery bypass grafting. Annals od cardiac anesthesia 2012;15[1]:39-43.