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Category: Volume 07 Issue 10 October 2019
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Title: RDW is Useful Predictor of Cardiovascular and Renal Disease of Patients Suffering from Subclinical Hypothyroidism Attending at Tertiary Care Hospital of NBMCH

Authors: Ashoke Kr Saha, Rajarshi Kayal, Saheli Kayal, Krishanu Banik

 DOI: https://dx.doi.org/10.18535/jmscr/v7i10.145

Abstract

Background:  Deficiency of thyroid hormones causes red cell disorder in our body. Anaemia is a common sign. Hypothyroid disorder patients have a decreased RBC mass due to reduction plasma volume. On routine examination such as hemoglobin estimation it may be missed because of increased RBC mass is observed in other causes of anaemia. Thyroid hormones have significant effects on renal haemodynamics and suspected cardiovascular diseases.

  1. To know the effect of SCH on 1) erythrocyte indices (HB, HCT, MCV & RDW-cv)
  2. Renal function parameters( urea, creatinine and e-GFR)
  3. Cardiovascular parameters (triglycerides, total cholesterol, HDL, LDL )
  4. Inflammatory marker i.e CRP

In our study ie hospital based observational study for one year. HB, HCT, MCV, RDW, FT4, TSH, TOTAL CHOLESTEROL, TRYGLYCERIDES, LDL, HDL, CRP, UREA, CREATININE were estimated and eGFR was calculated using modification  of diet in renal disease study equation. Higher RDW measurement have been strongly associated with low HDL cholesterol and an inverse and graded association between renal function was reported in our study.

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Corresponding Author

Rajarshi Kayal

Researcher, Ph.D in Biochemistry, Mritwika Appartment, P30 Gabtala Lane, , West Bengal, Kolkata 700060