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Category: Volume 07 Issue 10 October 2019
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Title: Association between Psoriasis and Metabolic Syndrome and its Correlation with Disease Type and Severity: A Case Control Study

Authors: Kalyan Dalave, Avinash Jadhav, Bhavika Shah, Pallavi Singh

 DOI: https://dx.doi.org/10.18535/jmscr/v7i10.66

Abstract

  

Introduction: Psoriasis is an immune-mediated disease leading to increased susceptibility to cardiovascular disease. The risk factors predisposing to cardiovascular disease are described as a cluster of features referred to as metabolic syndrome (MS). Previous studies have shown an association between the two.

Methods: The study was conducted in a tertiary hospital with 95 cases and 95 age and sex matched controls. A clinical examination of type and severity of disease was done. Blood pressure, waist circumference, fasting blood sugar and fasting lipid profile were assessed in all patients. Subsequently MS was diagnosed as per National Cholesterol Education Program (NCEP) - Adult Treatment Panel III as presence of 3 or more of the criteria.

Results: MS was found to be significantly more common in patients with psoriasis (p = 0.030). Of the individual components, those having significant association included hypertension (p=0.010), fasting blood sugar (p=0.021) and dyslipidemia (0.030). Increased waist circumference was more common in cases but association was not significant.  Study  had  77  (81.5%)  males  and  18  (18.95%)  female  patients  with mean age of the psoriatic patients being 45.5 ± 9.5 years. Most cases having positive association were of chronic plaque type while guttate and inverse psoriasis had no association

Conclusions: MS has higher prevalence in patients having psoriasis. All patients should be screened and monitored for the same.

Keywords: Metabolic syndrome, psoriasis, diabetes mellitus, hypertension, dyslipidemia.

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Corresponding Author

Dr Bhavika M Shah

Department of Dermatology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune