Title: A Retrospective Laboratory Study of the Spectrum of Haemoglobin Disorders in North Goa District Hospital
Authors: Dr Varsha Shailendra Munj, Dr Melanie Dias, Dr Nelishka Gomes
DOI: https://dx.doi.org/10.18535/jmscr/v7i10.45
Abstract
Introduction: Haemoglobinopathies are abnormal hemoglobin related disorders which constitute major bulk of non communicable genetic disease worldwide and in India.
Aim of the Study: To detect clinically significant hemoglobinopathy by analyzing hematological profile and CE- HPLC (High Performance Liquid Chromatography) with associated limitations – a lab perspective.
Materials and Methods: This study was carried out in the Department of Pathology, North District Hospital over a period of 2 years.(January 2017 to 2019). HbA, HbA2, HbF and other variants of hemoglobin were studied by HPLC
Results: 1084 patients were tested, 130 cases were detected having abnormal hemoglobin pattern on chromatogram.β Thalassemia trait constituted 89 cases followed by HbE trait (10 cases), HbS (7 cases), β Thalassemia major (4 cases) compound HbE with β Thalassemia (4 cases), HbS disease (3 cases) , HbD (3) ,δβ Thalassemia (3 cases), HPFH (2 cases) ,Compound HbE with δβ Thalassemia (1 case) , HbE disease (3 cases) and Compound HbS with β thalassemia (1 case). Additionally 18 cases (3 with abnormal initial peaks, 1 with high P3 and 14 cases with Borderline HbA2) were noted and 3 cases of borderline HbA2 were noted having macrocytic anemia
Conclusion: The present study provides a comprehensive data of the spectrum of hemoglobinopathies identified at North district hospital Goa reflecting the magnitude of the problem which may be just the tip of the iceberg. Hence, preventive and control measures need to be taken by the policy makers and the health care department of the state.
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