Title: A Descriptive Study of Vitamin D Deficiency in Chronic Urticaria and Its Possible Role in Pathogenesis
Authors: Premchand TR, Kaviarasan PK, Prasad PVS, Kannambal K, Poorana B, Abhirami C
DOI: https://dx.doi.org/10.18535/jmscr/v7i10.26
Abstract
Background: Chronic urticaria, though is not lethal, it significantly affects the quality of life of patients. The cause is idiopathic in 55% and autoimmune in 45% of chronic urticaria cases. Role of vitamin D3 in various immune mediated skin diseases like vitiligo, atopic dermatitis and psoriasis has been already explored and well established. It is now known that chronic urticaria is often triggered by autoimmune reactions, since vitamin D plays an important role in innate and adaptive immunity, it is more likely to be associated with chronic urticaria
Aim: The purpose of the present study was to evaluate the serum vitamin D3 levels and other clinical characteristics in patients of chronic urticaria.
Method: This is a descriptive study which was performed in about 36 subjects with chronic urtcaria who attended the outpatient Department of Dermatology in a tertiary care centre. Serum vitamin D3 levels were measured and stratified into vitamin D deficiency, insufficiency and sufficiency as per standard reference range and compared with healthy controls to ascertain the relationship between vitamin D status and chronic urticaria.
Results: Serum vitamin D3 level was significantly lower in chronic urticaria subjects as compared with the healthy controls. The prevalence of vitamin D deficiency (<30 ng/ml) was significantly higher in patients with chronic urticaria.
Conclusion: The present study showed a strong positive correlation between vitamin D deficiency and chronic urticaria. This study also warrants that each subject with chronic urticaria should be screened for serum vitamin D3 levels before initiating treatment.
Keywords: Chronic urtricaria, vitamin deficiency, VDR receptors, immunomodulatory, 5D pruritus score, Autologous Serum Skin Test (ASST).
References
- Bracken SJ, Abraham S, MacLeod AS. Autoimmune Theories of Chronic Spontaneous Urticaria. Front Immunol. 2019 Mar 29;10:627.
- Woo YR, Jung KE, Koo DW, Lee JS. Vitamin D as a Marker for Disease Severity in Chronic Urticaria and Its Possible Role in Pathogenesis. Ann Dermatol. 2015 Aug;27(4):423-30.
- Movahedi et al (2015). Vitamin D Deficiency in Chronic Idiopathic Urticaria. Iranian journal of allergy, asthma, and immunology.
- Baroni E, Biffi M, Benigni F, et al.: VDR-dependent regulation of mast cell maturation mediated by 1, 25-dihydroxyvitamin D3. J Leukoc Biol 2007, 81:250–262.
- Astri Adelia, Larisa Paramitha Wibawa, Adhimukti T Sampurna, Windy K Budianti, FaridaZubier. The role of oral vitamin D in several skin diseases J Gen Proceed Dermatol Venereol Indones. 2017;2(1):18-23.
- Chandrashekar, L., Rajappa, M., Munisamy, M., et al. (2014). 25-Hydroxy vitamin D levels in chronic urticaria and its correlation with disease severity from a tertiary care centre in South India. Clinical Chemistry and Laboratory Medicine (CCLM), 2019;52(6), pp. e115-e118.
- Kamini CR, Prasad PVS, Kaviarasan PK, Kannambal K A prospective analysis on relationship between serum IgE levels and severity of chronic urticaria Global Journal For Research Analysis,Volume-5, Issue-10, October 2016.
- Bajaj A K, Saraswat A, Upadhyay A, Damisetty R, Dhar S. Autologous serum therapy in chronic urticaria: Old wine in a new bottle. Indian J Dermatol Venereol Leprol 2008;74:109-13.
- Tuchinda, Papapit et al. “Relationship between vitamin D and chronic spontaneous urticaria: a systematic review.” Clinical and translational allergy (2018).