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Category: Volume 07 Issue 06 June 2019
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Title: Mucin Histochemical Features of Esophageal Adenocarcinoma as a Predictor of Prognostic Outcome: A Clinicopathological and Histochemical Study

Authors: Dr Chandranath Banerjee, Dr Diptimay Das, Dr Debjit Ghosh

 DOI: https://dx.doi.org/10.18535/jmscr/v7i6.145

Abstract

Aim: The aim of this study is to evaluate the various clinicopathological factors and correlate with mucin  histochemical features in patients with the adenocarcinoma of the esophagus, all of whom underwent total esophagectomy.

Material & Method: Data of a total of forty five patients with adenocarcinoma of the esophagus, all patients having undertaken total esophagectomy at Department of Surgery, AIIMS, New Delhi in between January 1980 and December 1995, were retrospectively analysed for study. All these patients were divided into two groups, cases (21) and controls (24); depending on the outcome of interest at 24 months (i.e. death or survival); controls being the patients, who survived for 24 months. Patients were evaluated with reference to clinicopathological variables and mucin histochemistry. Sections were stained by the Alcian Blue / Periodic Acid Schiff & High iron Diamine Alcian Blue technique to identify neutral mucin and acid mucin (sialomucin and sulphomucin).

Results:  It is apparent from this study, that the well-known clinicopathological variables like age, sex, consumption of tobacco &alcohol, symptoms, location, differentiation, stage, that affect survival were in no way different in cases and controls. Therefore, role of mucin histochemical characteristics were explored and it was found that presence of mucin (acid / neutral) in any location (intracellular / extracellular) may be associated with poor prognosis. Again among the extracellular acid mucins, sulphomucin is almost associated with worse prognosis.

Conclusion: Well known clinicopathological variable that affect poor survival were analysed retrospectively, for adenocarcinoma esophagus who underwent esophagectomy; 24 months being taken as the outcome of interest (death or survival); control were the patients who survived for 24 months. No statistically significant difference was found among clinicopathological variables. However, mucin histochemical characteristics and amongst these extracellular acid mucin; sulphomucin is almost always associated with poor prognosis.

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Corresponding Author

Dr Diptimay Das

Associate Professor, Department of Radiotherapy, Burdwan Medical College & Hospital