Title: Diagnostic capability of EEG in Alzheimer's Disease Related Dementias
Authors: Dr V.S. Pal, Dr Vijay Niranjan, Dr Abhay Paliwal, Dr Atar Singh
DOI: https://dx.doi.org/10.18535/jmscr/v7i6.135
Abstract
Background: With significant increases in life expectancy the number of person with dementia are also climbing. There is no confirmatory test to diagnose dementia. Doctors diagnose dementia based on a medical history, a physical examination, and the characteristic changes in thinking, day-to-day function and behavior. Certain diagnosis of dementia is only possible after post-mortem exam. Efforts are being made to diagnose these neurodegenerative disorders in the early stages.
Aims & Objectives: 1) Aim: - To study Diagnosis capability of EEG in dementia.
2) To study EEG changes in different parts of brain by using 32 channels, 24 lead EEG machine.
Material & Methods: The study was conducted by including patients and healthy elderly controls above age 55 years. Subjects were taken from Dept of psychiatry, MGM Medical College and MYH, Indore fulfilling the inclusion and exclusion criteria. Written informed consent will be taken after explaining the objectives and procedure of study in detail. The EEG of participants has been recorded in Mental Hospital Banganga by using departmental RMS® EEG Systems Maximus version 4.2.54. © 2007-2008. Data were entered in excel sheet and analyzed using SPSS Software, appropriate statistical test was applied wherever necessary.
Results: Participants with dementia have slow waves preponderance as compare to control.
Conclusion: EEG can be used to differentiate person with dementia with healthy individual.
Keywords: EEG, dementia
References
- Berchtold, N.C. and Cotman, C.W. (1998): Evolution in the conceptu-alization of dementia and Alzheimer’s disease: Greco-Roman period to the 1960s. Neurobiol Aging 19, 173–189
- Katzman R (April 1976). "Editorial: The prevalence and malignancy of Alzheimer disease. A major killer". Archives of Neurology. 33 (4): 217–18.
- Alva G, Potkin SG (2003): Alzheimer disease and other dementias. Clin Geriatr Med; 19(4):763–776
- Korf ES, Wahlund LO, Visser PJ, Scheltens P (2004): Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment. Neurology 63: 94–100.
- Mosconi L, Mistur R, Switalski R, Tsui WH, Glodzik L, Li Y, Pirraglia E, De Santi S, Reisberg B, Wisniewski T, de Leon MJ (2009): FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer’s disease. Eur J Nucl Med Mol Imaging; 36: 811–822.
- Claus JJ, Strijers RL, Jonkman EJ, (1999). The diagnostic value of electroencephalography in mild senile Alzheimer’s disease. Clin Neurophysiol; 110:825–832.
- Steven Michael Snyder, James Richard Hall, Sonya Lynn Cornwell, James David Falk,(2011) Addition of EEG improves accuracy of a logistic model that uses neuropsychological and cardiovascular factors to identify dementia and MCI, Psychiatry Research,186 (1) 97-102.
- Gearing M, Mirra S S,Hedreen J C,SumiS M, Hansen L A, Heyman A (1995). The consortium to establish a registry for Alzheimer’s disease(CERAD).Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer’s disease. Neurology 45(3)461-6.
- Dubois M F, Hebert R (2001): The incidence of vascular dementia in Canada: a comparison with Europe and East Asia. Neuroepidemiology 20(3):179–87.
- Moretti, Davide & Zanetti, Orazio & Binetti, Giuliano & Frisoni, Giovanni. (2012). Quantitative EEG Markers in Mild Cognitive Impairment: Degenerative versus Vascular Brain Impairment. International journal of Alzheimer's disease. (7) 75-7.
- Hennie Lee and Geert J F Brekelmans and Gerwin Roks (2015) The EEG as a diagnostic tool in distinguishing between dementia with Lewy bodies and Alzheimer’s disease, Clinical Neurophysiology,126,1735-1739.
- Fratiglioni L, Viitanen M, von Strauss E (1997). Very old women at highest risk of dementia and Alzheimer disease: incidence data from the Kungsholmen Project, Stockholm. Neurol ;48:132-138.
- Letenneur L, Gilleron V, Commenges (1999). Are sex and educational level independent predictors of dementia and Alzheimer’s disease? Incidence data from the PAQUID project. J Neurol Neurosurg Psychiatry. 66:177-183.
- Edland SD, Rocca WA, Petersen RC (2002): Dementia and Alzheimer disease incidence rates do not vary by sex in Rochester, MN. Arch Neurol. 59:1589-1593
- Matthews FE, Stephan BC, Robinson L (2016). A two-decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II. Nat Commun. 7:11398.
- Sayegh, P., & Knight, B. G. (2013). Cross-cultural differences in dementia: the Sociocultural Health Belief Model. International Psychogeriatrics, 25(4), 517-530.