Title: Fibrothecoma of Ovary with Elevated Ca125 Levels and Ascitis - A Case Report
Authors: Parveen Rana Kundu, Amrita Kulhria, Swaran Kaur, Monika Breta Gathwal, Anu Sharan, Anjali Sindhu
DOI: https://dx.doi.org/10.18535/jmscr/v7i6.127
Abstract
Introduction: Ovarian fibrothecomas are uncommon, benign tumors of gonadal stromal cell origin. They account for 3–4% of all ovarian neoplasm and are rarely malignant. CA 125 is usually normal.
Case Report: A case of ovarian fibrothecoma in a postmenopausal woman who presented with complains of something coming out of vagina (uterine prolapse), abnormal uterine bleeding and abdominal distension for 6 months. CA 125 levels were also raised.
Conclusion: Fibrothecomas are solid, uncommon ovarian neoplasm. It is to be differentiated from other solid neoplasm of ovary in post menopausal women.
Keywords: Fibrothecoma, Ovary, CA 125.
References
- Outwater EK, Wagner BJ, Mannion C, McLarney JK, Kim B. Sex cord-stromal and steroid cell tumors of the ovary. Radiographics 1998; 18: 1523–46.
- Chechia A, Attia L, Temime RB, Makhlouf T, Koubaa A. Incidence, clinical analysis, and management of ovarian fibromas and fibrothecomas. Am J ObstetGynecol 2008; 199(473): 1-4.
- Dhull A, Kaushal V, Mathur S, Agarwal R. Fibrothecoma of the Ovary- A Rare Case Presentation. The Internet Journal of Third World Medicine 2010; 9(2): 1-4.
- Bazot M, Ghossain MA, Buy JN, Deligne L, Hugol D, Truc JB, et al. Fibrothecomas of the ovary: CT and US findings. J Comput Assist Tomogr 1993; 17: 754–59.
- Imaoka I, Wada A, Kaji Y, Hayashi T, Hayashi M et al. Developing an MR imaging strategy for diagnosis of ovarian masses. Radiographics 2006; 26: 1431–48.
- Takeshita T, Shima H, Oishi S, Machida N, Yamazaki K et al. Ovarian fibroma (fibrothecoma) with extensive cystic degeneration: unusual MR imaging findings in two cases. Radiat Med 2005; 23: 70–74.
- Tavassoli FA, Devilee P, eds. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Lyon, France: IARC Press; 2002.World Health Organization Classification of Tumours; vol 5.
- Renaud MC, Plante M, Roy M. Ovarian thecoma associated with a large quantity of ascites and elevated serum CA 125 and CA 15-3. J Obstet Gynaecol Can. 2002; 24: 963–65.
- Young RH, Scully RE. Sex cord stromal, steroid cell and other ovarian tumors with endocrine, paraendocrine and paraneoplastic manifestations. In: Kurman RJ, ed. Blaustein’s Pathology of the Female Genital Tract. 5th ed. New York, NY: Springer-Verlag; 2002.
- McCluggage WG, Sloan JM, Boyle DD, Toner PG. Malignant fibrothecomatous tumour of the ovary: diagnostic value of anti-inhibin immunostaining. J Clin Pathol 1998; 51: 868–871.
- Lee H, Ahmed Q. Fibrosarcoma of the ovary arising in a fibrothecomatous tumor with minor sex cord elements: a case report and review of literature. Arch Pathol Lab Med. 2003; 127: 81–84.
- Samanth KK, Black WC. Benign ovarian stromal tumors associated with free peritoneal fluid. Am J Obstet Gynecol 1970; 107: 538-45.
- Costa MJ, Morris R, DeRose PB, Cohen C. Histologic and immunohistochemical evidence for considering ovarian myxoma as a variant of the thecoma-fibroma group of ovarian stromal tumors. Arch Pathol Lab Med 1993;117: 802-8.
- Troiano RN, Lazzarini KM, Scoutt LM, Lange RC, Flynn SD et al. Fibroma and fibrothecoma of the ovary: MR imaging findings. Radiology 1997; 204: 795-98.
- Nogales FF, Martin-Sances L, Mendoza-Garcia E, Salamanca A, Gonzalez-Nunez MA et al. Massive ovarian oedema. Histopathology 1996; 28: 229-34.
- Scully RE, Youg RH, Clement PB. Tumors of the ovary, maldeveloped gonads, fallopian tube and broad ligament. Washington DC, AFIP, 1996. P. 189-201.