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Category: Volume 07 Issue 06 June 2019
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Title: Comparison of Suxamethonium and Rocuronium on time to Oxygen Desaturation during Apnoea Following Rapid Sequence Induction- A Randomized Controlled Trial

Authors: Dr Malyashree Roy M.D, Dr Neetika Mishra M.D, Dr Ahito Kibami M.B.B.S

 DOI: https://dx.doi.org/10.18535/jmscr/v7i6.124

Abstract

Hypoxia and hypoxic related injuries remain the main cause of anaesthesia related death and serious morbidity. The study has been focused on maximising the intrapulmonary oxygen reserve to prolong non-hypoxic apnoea duration. Various technique of preoxygenation including rebreathing with high fresh gas flow, application of positive airway pressure during preoxygenation, nasopharyngeal oxygen insufflation following preoxygenation can delay the onset of arterial desaturation during apnoea. The present study was carried out with the primary objective of comparing between suxamethonium and rocuronium as agent for rapid sequence induction with respect to the time required for oxygen saturation to decrease to 92% in seconds following apnoea. It was hypothesized that suxamethonium would be associated with shorter time to desaturate from administration until oxygen saturation was 92%.

In the present studies 66 patients were divided into two groups: Group S (n=33) for suxamethonium and Group R (n=33) for rocuronium and their datas was analysed.

Significant difference was detected in the time taken for oxygen saturation to decreased to 92% between the two group (p=0.042). Haemodynamic parameters both at intubation and post-intubation at 2minutes were comparable and showed no significant differences.

Keywords: safe apnea, suxamethonium, rocuronium, rapid sequence intubation.

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Corresponding Author

Dr Neetika Mishra M.D

Associate Professor, Dept. of Anaesthesiology, North Bengal Medical College, Darjeeling, West Bengal