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Category: Volume 07 Issue 06 June 2019
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Title: Incidences of Acute Lymphoblastic Leukemia as per Age: A two year Study

Authors: Prof. Dr Ashok Panchonia, Dr Sachin Sharma, Prof. Dr Nirbhay Mehta, Dr Rakesh Mehar, Dr Varsha Argal

 DOI: https://dx.doi.org/10.18535/jmscr/v7i6.99

Abstract

Objective: ALL is the most common cancer in children. Global incidence is about 3 per 100,000 populations, in which 3 out of 4 cases occurring under 6 years  age. ALL accounts for 12% of all leukemia (but 80% in children). Much progress has been made in the treatment of acute lymphoblastic leukemia (ALL, which constitute 75–80% of childhood acute leukemia’s with raised 5-year overall survival rate which reaches up to 90% in the high-income countries (HICs).

Aims & Objectives: To find out the age wise incidences of acute lymphoblastic leukemia. 

Material & Methods: A two year study was conducted in the department of Pathology M.G.M. Medical College Indore. Patients were diagnosed on the basis of peripheral smear then further confirmation was done with the help of flow cytometry.  The results were then evaluated for age wise incidences.

Results: We have observed that the incidences of acute lymphoblastic leukemia are common in children’s with age less than 15 years.

Conclusion: Acute lymphoblastic leukemia is more common in childhood. It is also noted that the incidence of ALL is slightly higher in males compared to females

Keywords: Acute leukemia, childhood, flowcytometry.

References

  1. Sawyers CL, Denny CT, Witte ON. Leukemia and the disruption of normal hematopoiesis. Cell. 1991;64(2):337–50.
  2. Stiller CA, Parkin DM. Geographic and ethnic variations in the incidence of childhood cancer. Br Med Bull. 1996; 52:682–703. 
  3. Arora RS, Eden TO, Kapoor G. Epidemiology of childhood cancer in India. Indian J Cancer. 2009;46:264–73. 
  4. Sather HN. Age at diagnosis in childhood acute lymphoblastic leukemia. Med Pediatr Oncol. 1986;14(3):166–72.
  5. Gurney JG, Severson RK, Davis S, Robison LL. Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type. Cancer. 1995;75(8):2186–95.
  6. Hossain MJ, Xie L, McCahan SM. Characterization of pediatric acute lymphoblastic leukemia survival patterns by age at diagnosis. J Cancer Epidemiol. 2014;2014:865979
  7. Cortes JE, Kantarjian HM. Acute lymphoblastic leukemia. A comprehensive review with emphasis on biology and therapy. Cancer. 1995;76(12):2393–417.
  8. Katz AJ, Chia VM, Schoonen WM, Kelsh MA. Acute lymphoblastic leukemia: an assessment of international incidence, survival, and disease burden. Cancer Causes Control. 2015;26(11):1627–42.
  9. Pratt CB. Some aspects of childhood cancer epidemiology. Pediatr Clin N Am. 1985;32(3):541–56.
  10. Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ, Reaman GH, Carroll WL. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group. J Clin Oncol. 2012;30 (14):1663–9.
  11. Kulkarni K, Stobart K, Witol A, Rosychuk RJ. Leukemia and lymphoma incidence in children in Alberta, Canada: a population-based 22-year retrospective study. Pediatr Hematol Oncol. 2011;28(8):649–60.

Corresponding Author

Dr Varsha Argal