Title: Comparison of Low-Dose and Standard-Dose CT in Patients with Clinically Suspected Urolithiasis: A Prospective Study

Authors: Manik Mahajan, Poonam Sharma

 DOI: https://dx.doi.org/10.18535/jmscr/v7i6.96

Abstract

Background: The prevalence and recurrence of urolithiasis are high; particularly in the north-western part of India. Ultrasonography has poor sensitivity and specificity compared to Non Contrast Computed Tomography (CT) for detection of both renal and ureteral calculi. Drawbacks of Non contrast CT include radiation exposure which can be overcome by low-dose CT protocols. Low-dose CT may be a useful investigation with high diagnostic accuracy and less radiation hazards in evaluating urolithiasis.

Aim: To compare efficacy of low-dose non contrast CT with standard-dose CT in the detection of urolithiasis

Material and Methods: Fifty cases of clinically suspected urolithiasis underwent both abdominal standard-dose CT (140 mAs) and low-dose CT (70 mAs) with fixed kVp (120). Patients with BMI <30 (non obese) were included in the study. Both the scans were independently reviewed by two radiologists for the characterization of urolthiasis and any indirect signs of renal and ureteral colic. Results for low-dose CT were compared with those obtained with standard-dose CT (reference standard).

Results: Majority of patients were seen in 3rd decade with male to female ratio of 1:8. Eighty Eight calculi were detected in 50 patients. Low-dose CT had approx. 82% and 100% sensitivity in identifying renal calculi <5mm and >5mm size respectively while it had approx. 92% sensitivity for the detection of ureteric calculi. Mean effective radiation dose in standard-dose CT and low-dose CT was 2.1 mSv and 4.3 mSv respectively.

Conclusions: Low-dose CT provides effective method of identifying and evaluating urolthiasis with high diagnostic accuracy and sensitivity and significant dose reduction as compared to standard-dose CT.

References

  1. Sharma S, Chaudhari, Rawal K, Khant S. Low dose computed tomography KUB region for management of urolithiasis in Indian scenario. Int Surg J. 2018 Feb;5(2):638-642.
  2. Bhatt K, Monga M, Remer EM. Low-Dose Computed Tomography in the Evaluation of Urolithiasis. J Endourol.2015 May;29(5):504-11.
  3. Ansari MS, Gupta NP, Hemal AK, Dogra PN, Seth A, Aron M, et al. Spectrum of stone composition: Structural analysis of 1050 upper urinary tract calculi from northern India. Int J Urol.2005 Jan;12(1):12-6.
  4. Teichman JM. Clinical practice: acute renal colic from ureteral calculus. N Engl J Med.2004 Feb 12;350(7):684-93.
  5. Abramson S, Walders N, Applegate KE, Gilkeson RC, Robbin MR. Impact in the emergency department of unenhanced CT on diagnostic confidence and therapeutic efficacy in patients with suspected renal colic: a prospective survey. AJR Am J Roentgenol.2000 Dec;175(6):1689-95.
  6. Niemann T, Kollmann T, Bongartz G. Diagnostic performance of low-dose CT for the detection of urolithiasis: A meta-analysis. AJR Am J Roentgenol.2008 Aug;191(2):396-401.
  7. Meagher T, Sukumar VP, Collingwood J, Crawley T, Schofield D, Henson J et al. Low dose computed tomography in suspected acute renal colic. Clin Radiol.2001 Nov;56(11):873-6.
  8. Hamm M, Knopfle E, Wartenberg S, Wawroschek F, Weckermann D, Harzmann R. Low dose unenhanced helical computerized tomography for the evaluation of acute flank pain. J Urol.2002 Apr;167(4):1687-91.
  9. Kim BS, Hwang IK, Choi YW, Namkung S, Kim HC, Hwang WC et al. Low-dose and standard-dose unenhanced helical computed tomography for the assessment of acute renal colic: prospective comparative study. Acta Radiol.2005 Nov;46(7):756-63.
  10. Liu W, Esler SJ, Kenny BJ, Goh RH, Rainbow AJ, Stevenson GW. Low-dose non enhanced helical CT of renal colic: assessment of ureteric stone detection and measurement of effective dose equivalent. 2000 Apr;215(1):51-4.
  11. Tack D, Sourtzis S, Delpierre I, de Maertelaer V, Gevenois PA. Low-dose unenhanced multidetector CT of patients with suspected renal colic. AJR Am J Roentgenol.2003 Feb;180(2):305-11.
  12. Kluner C, Hein PA, Gralla O, Hein E, Hamm B, Romano V et al. Does ultra-lowdose CT with a radiation dose equivalent to that of KUB suffice to detect renal and ureteral calculi? J Comput Assist Tomogr.2006 Jan-Feb;30(1):44-50.
  13. Shrimpton P. Assessment of patient dose in CT. In: EUR. European guidelines for multislice computed tomography funded by the European Commission 2004: contract number FIGMCT2000-20078-CT-TIP. Luxembourg, Luxembourg: European Commission, 2004:Appendix C
  14. Shrimpton PC, Hillier MC, Lewis MA, Dunn M. Doses from computed tomography (CT) examinations in the UK: 2003 review. Chilton, UK: National Radiological Protection Board, 2005:report NRPB-W67.
  15. Şalk İ, Çetin A, Korkmaz İ, Sezer F, Atalar MH. Place of non-contrast computed tomography for evaluation of flank pain and suspected urinary stone in emergency service. Cumhuriyet Med J 2014;36:42-50.
  16. Dalla Palma L, Pozzi-Mucelli R, Stacul F. Presentday imaging of patients with renal colic. Eur Radiol.2001;11(1):4-17.
  17. Dalrymple NC, Verga M, Anderson KR, Bove P, Covey AM, Rosenfield AT et al. The value of unenhanced helical computerized tomography in the management of acute flank pain. J Urol.1998 Mar;159(3):735-40.
  18. Miller OF, Kane CJ. Time to stone passage for observed ureteral calculi: a guide for patient education. J Urol.1999 Sep;162(3 Pt 1):688-90; discussion 690-1.
  19. Varanelli MJ, Coll DM, Levine JA, Rosenfield AT, Smith RC. Relationship between duration of pain and secondary signs of obstruction of the urinary tract on unenhanced helical CT. AJR Am J Roentgenol.2001 Aug;177(2):325-30.
  20. Coll DM, Varanelli MJ, Smith RC. Relationship of spontaneous passage of ureteral calculi to stone size and location as revealed by unenhanced helical CT. AJR Am J Roentgenol.2002 Jan;178 (1):101-3.
  21. Poletti PA, Platon A, Rutschmann OT, Verdun FR, Schmidlin FR, Iselin CE et al. Abdominal plain film in patients admitted with clinical suspicion of renal colic: should it be replaced by low-dose computed tomography? 2006 Jan;67(1):64-8.
  22. Poletti PA, Platon A, Rutschmann OT, Schmidlin FR, Iselin CE, Becker CD . Low-dose versus standard-dose CT protocol in patients with clinically suspected renal colic. AJR Am J Roentgenol. 2007 Apr;188(4):927-33.

Corresponding Author

Manik Mahajan

House no 109, Sector-7, Channi Himmat, Jammu (J&K), India – 180015