Title: To Study Pulmonary Complications in Patients Living with HIV (PLH) in a Tertiary Care Hospital in India

Authors: Manoj Kumar, Arun Kumar, Kiran Krishnappa, Vijayavarman V, Sanjeev Kumar Pandey

 DOI: https://dx.doi.org/10.18535/jmscr/v7i6.93

Abstract

Background: Pulmonary disease is one of the most frequent complications of HIV infection. Three of the 10 most common AIDS-defining illnesses are recurrent bacterial pneumonia, tuberculosis, and pneumonia due to the unicellular fungus P. jirovecii1.Pneumocystis jirovecii pneumonia is hallmark of AIDS2.

Aims and Objectives : To study pulmonary complications in people living with HIV and radiological findings in lungs of PLHIV with pulmonary disease by Digital chest X-ray, HRCT (High resonance computed tomography) Thorax.

Material and Methods: Study period for this cross sectional study was from December 2018 to January 2019 and the total number of HIV patients admitted on IPD and OPD basis who fulfil inclusion and exclusion criterion was 60 in this duration with pulmonary involvement. The distribution of disease was expressed in proportion.

Results: In pulmonary tuberculosis patients with HIV, consolidation was most common finding on both digital chest x- ray and HRCT thorax. Prevalence of Pneumocystis jiroveci pneumonia, tuberculosis and Bacterial pneumonia was maximum in patient having cd4 count <50,200-500, >200/micro litre respectively. In pneumocystis jiroveci pneumonia maximum patients had ground glass haziness on chest X ray, prevalence of lower zone involvement was maximum followed by upper zone.

Conclusion: Prevalence of tuberculosis was maximum in patient with HIV followed by bacterial pneumonia and pneumocystis jiroveci pneumonia respectively. Most of the bacterial pneumonia patients had consolidation on digital chest x-ray (PA view) and most of the patients with ground glass haziness on chest x ray have pneumocystis jiroveci pneumonia infection.

Keywords: Pneumocystis jiroveci, PLHIV, HRCT, AIDS.

References

  1. Skalski JH, Limper AH. “Fungal, Viral, and Parasitic Pneumonias Associated with Human Immunodeficiency Virus”. Semin Respir Crit Care Med. 2016 Apr;37(2):257-66.
  2. Su YS, Lu JJ, Perng CL, Chang FY. “Pneumocystis jirovecii pneumonia in patients with and without human immunodeficiency virus infection”. J Microbiol Immunol Infect. 2008 Dec;41(6):478-82.
  3. Triplette M, Crothers K, Attia EF. “Non-infectious Pulmonary Diseases and HIV”. Curr HIV/AIDS Rep. 2016 Jun;13(3):140-8.
  4. Wissmann,Y De Armas Rodríguez et al. “Pneumocystis jirovecii pneumonia in developing countries”. Parasite. 2011 Aug; 18(3): 219–228.
  5. William R. Bishai, Mandeep S. Jassal .” The Epidemiology and Challenges to the Elimination of Global Tuberculosis”. Clin Infect Dis. 2010 May 15; 50(0 3): S156–S164.
  6. Sun Hee Lee, Kye-Hyung Kim, Seung Geun Lee et al.” Causes of Death and Risk Factors for Mortality among HIV-Infected Patients Receiving Antiretroviral Therapy in Korea”. J Korean Med Sci. 2013 Jul; 28(7): 990–997.
  7. Peloquin CA.” Mycobacterium avium complex infection. Pharmacokinetic and pharmacodynamic considerations that may improve clinical outcomes”. Clin Pharmacokinet. 1997 Feb;32(2):132-44.
  8. Mehta AA, Kumar VAm et al. “Clinic -epidemiological profile of HIV patient with respiratory infection and tuberculosis in western India”. Journal of Clinical and Diagnostic Research2011; 5:206-209.
  9. Toshniwal SP, Mathpati SM et al. “Respiratory complication in human immunodeficiency virus seropositive patient in co-relation to cd4 counts: an observational cross-sectional study”. International Journal of Scientific Study 2014; 2:1-5.
  10. Halgarkar CS, Nilekar SL. “HIV prevalence and the co-relation of different opportunistic infection with CD4 cell count”.Indian Medical GAZETTE2014; 157-160.
  11. Ahidjo A, Yusuph H et al . Radiographic features of pulmonary tuberculosis among HIV patient in MAIDUGIRI, Nigeria, annuals of African medicine 2005; 4:7-9.
  12. pu –xuanliu, ying –yingdeng et al”correlation between imaging features of pneumocystis jiroveci pneumonitis, cd4 T lymphocyte count and plasma HIV viral load: A study in 50 consecutive AIDS patient”. Quant Imaging Med Surg2012; 2:124-129.

Corresponding Author

Arun Kumar

3rd year, PG Resident Department General Medicine, UPUMS Saifai, Etawah (Uttar Pradesh), India