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Category: Volume 07 Issue 06 June 2019
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Title: A Prospective Evaluative Study between Low Dose Ketamine and Fentanyl as Pre Medication for Alleviation of Propofol Injection Pain

Authors: Mohamad Ommid, Saba Ahad, Shazada Gani , Faisal Rasool Dar, Mushtaq Rather, Humera Manzoor

 DOI: https://dx.doi.org/10.18535/jmscr/v7i6.88

Abstract

Purpose: To evaluate the pain on injection of propofol via pretreatment with low dose of ketamine and low dose of   Fentanyl in patients undergoing elective surgery under general anaesthesia.

Methods: Total 60 patients were randomly allocated into two groups 6 groups. Group K (Ketamine Group): Received ketamine 0.15 mg/kg iv, 1 minute before injection of propofol and Group F (Fentanyl Group): Received Fentanyl 1.5mcg/kg iv, 1 minute before injection of propofol. All patients were monitored for the blood pressure (MAP), heart rate (HR), and oxygen saturation (SpO2). Additionally, the pain intensity was assessed using a 4-point verbal rating scale (VRS) by professional doctors.

Results: The incidence of pain due to propofol injection in Group K 22 (62.85%) of the patients did not represent any pain and in Group F 24 (68.27%) of the patients does not show any pain during propofol injection. However, the difference between the two groups was statistically insignificant with p value of 0.782.

Conclusion: From the findings of our study, it may be concluded that pre-treatment with low dose intravenous ketamine 0.15mg/kg and intravenous Fentanyl 1.5mcg/kg with a tourniquet just before propofol injection, significantly reduced the incidence and degree of propofol induced pain without significant adverse hemodynamic effects.

Keywords: General surgery, Propofol. Fentanyl. Ketamine, pain.

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Corresponding Author

Dr Mohamad Ommid

Associate professor, Department of Anesthesiology & Critical Care, Govt. Medical College, Srinagar, India