Title: Study of Histochemistry of Endometrium in Infertility

Authors: Dr Shazia Nisar, Dr Shahzada Shahid Banday, Dr Juveria Wani

 DOI: https://dx.doi.org/10.18535/jmscr/v7i6.59

Abstract

A study of histochemistry of endometrium in infertility was done in department of gynae and obstetrics Skims soura.50 cases of infertility both primary and secondary were studied during period of one year. Premenstrual Endometrial biopsy was done and specimen was stained by H and E stains.

Aims and Objectives

  • To study histochemistry of endometrium in infertility
  • Their chances of achieving a successful pregnancy.

Inclusion Criteria

All cases of infertility both primary as well as secondary

Results: Total no. of cases taken were 50.those with primary infertility were 80% and those with secondary infertility were 20%.Maximum patients were in age group of 20-30 years. Morphorlogical changes noticed were Secreatory endometrium in 64% of primary and secondary infertility. Proliferative anovulatory in 13 cases, 26% of primary and secondary infertility, cystoglandular in 8%(4cases) and Tubercular endometritis in 2%(1 case)

Conclusion: Premenstrual Endometrial biopsy is thus important tool in assessing morphological changes of endometrium in infertility.

References

  1. Kleegman sj,kaufmann SA(1966) Infertility in women. Ist edn ,FA Davis company publisher , Philadelphia, USA,PP:178.
  2. Sahmay S,oral E, Saridogan E,Senturk L, Atasu T. Endometrial biopsy findings in infertility: analysis of 12,949 cases. Int J Fertil Menopausal Stud 1995;40:316_21
  3. Strowitzki T,Germeyer A, Popovici R,Von Molf M.The human endometrium as a fertility determining factor. Hum Reproduction update 2006;12:617_30
  4. Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional and global trends in infertility since 1990:A systematic analysis of 277 health surveys . Edited by PLOS Med. 2012; 9: e 1001356.EPub 2012 Dec 18 dol;10 .1371/journal .pmed..10001356
  5. Dawn CS (1976) textbook of gyneacology, 5 Edn, Dawn books, Calcutta India.
  6. Bessmertnaia vs, Samoilov Mv, Serebrennikova KG, Babichenko II. Endometrial morphological and immunohistochemical features in females with primary and secondary infertility. Arkh Patel 2008;70:31_4
  7. Kurabayashi T,Kase H, Suzuki M,Sugaya S, Fujita K,Tanaya K.Endometrial abnormalities in infertile women.J Reprod Med 2003;48:455_9.
  8. Dallenbach H (1980) Histopathology of endometrium,4th edn, Springer Verlag, Berlin.
  9. Majhi Ak(2002) luteal phase defect :still a mystery in female infertility .obstet gynaecol today.
  10. Jones GS(1976).The luteal phase defect Fertil Steril 27:351_356
  11. Gupta AN, vashishtak AS(1980)study of endometrium in infertile women .J obstet Gynaecol India.
  12. EmokPac MA,Uadia Po, Mohammed AZ. Hormonal evaluations and Endometrial biopsy in infertile women in Kano, Northern Nigeria: A comparative study Ann Afr Med 2005;4:99_103.
  13. IKeme AC, Ezegwui HU, Histological analysis of Endometrial currettings performed for infertility in Nigeria.j obstet Gynaecol 2004;24:914_5.
  14. Jadhav Mv,Raichur Bs(1987) special stains in study of normal and abnormal endometrium.Indian J pathol Microbiol 30:307_311.
  15. Shastrabudhe NS,Shinde S,Jadhav Mv (2001). Endometrium in infertile women .J obstet Gynaecol.
  16. Wentz AC, Kossoy LR,Parker RA (1990). The impact of luteal phase inadequacy in infertile population .AmJ obstet Gynaecol 162:937_943.
  17. Soules MR (1987) Luteal phase deficiency. An under diagnosed and over treated reproductive endocrine disorder. obstet Gynaecol Clin North Am 14:865_886.
  18. Mridu M,khanna S,Kahlon Sk(1993) Genital tuberculosis.Asian J obstet 1993.
  19. Kumar A Gupta N(2000) Genitaln tuberculosis. Asian J obstet Gynaecol.
  20. Tripathy SN,Tripathy SN(2002). Infertility and pregnancy outcome in female genital tuberculosis.Int J Gynaecol obstet 76:159_163.
  21. Scaefer G (1976) Pelvic tuberculosis.clin obstet Gynaecol.
  22. Zendek B,Shapino A(1942) Endometrial glycogen content in infertility.Amj obstet.
  23. Sharma SC,Hasan Bk(1984). Endometrial glycogen in sterility.
  24. Schaefer G(1976). Female genital tuberculosis. Clin obstet Gynaecol 19:223_239.
  25. Scaefer G(1976) .pelvic tuberculosis .clin obstet Gynaecol.
  26. Baveja R,verma Hc(1972) Endometrial glycogen in infertility.proc all India obstet gynaecol Cong.
  27. Gupta PL,Jethani M(1994). Endometrial glycogen an important parameter of infertility.J obstet Gynaecol India.

Corresponding Author

Dr Shazia Nisar

Senior Resident Department of Obstetrics and Gynaecology Skims Soura, India