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Category: Volume 07 Issue 04 April 2019
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Title: Is epithelial cell abnormality in cervical samples along with E6/7 mRNA expression of human Papilloma virus is correlated with socioeconomic status

Authors: Dr Khushboo Likhar, Prof. Dr C.V. Kulkarni, Dr Ankesh Kumar Jain, Prof. Dr Meena Mittal, Prof. Dr Ashok Panchonia, Dr Priya Jain

 DOI: https://dx.doi.org/10.18535/jmscr/v7i4.95

Abstract

Introduction

Cervical cancer ranked second among most commonly diagnosed cancer and in less developed countries it is third leading cause of cancer related death among females1,2,3 Cancer cervix is a multifactorial disease. Major risk factors are age4,5, illiteracy, low socioeconomic status, early menarche, marital status, early marriage, early first childbirth, age at last child birth, multiparity, abortion, multiple sexual partners, late menopause, genital infection, poor genital hygiene, tobacco use, passive smoking and contraceptive use 6-10. Other risk factors includes co-infection with Chlamydia trachomatis, non-use of condoms by partners and nutritional factors.11-16

Human Papilloma virus (HPV) infection is the most important risk factor. 17 It has been shown recently that cervical cancer is strongly associated with the presence of high risk or oncogenic Human Papilloma virus (HPV) types (up to 100%).18,19 it is the expression of viral oncogenes E6 /E7 which is  prerequisite for progression toward malignancy and maintenance of the cancerous phenotype20,21. As the severity of the lesion increases levels of E6/E7 also rises.22,23 E6 and E7 transcripts could be useful as markers of disease progression.22

Aims and Objectives

This study is carried out to correlate impact of socioeconomic status on occurrence of epithelial cell abnormality reported on cervical Pap smear study using 2014 Bethesda System and flow cytometry detection of HPV mRNA expression in present scenario.

References

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Corresponding Author

Dr Priya Jain

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