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Category: Volume 07 Issue 03 March 2019
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Title: Immunohistochemistry study for HER2/neu expression in pre-neoplastic and neoplastic lesions of uterine cervix

Authors: Dr Lata Choudhary, Dr A.D Dwivedi, Dr Vivek Gupta, Dr Vijai Singh

 DOI: https://dx.doi.org/10.18535/jmscr/v7i3.233

Abstract

Objective: To assess immunohistochemistry for HER2/neu expression in preneoplastic and neoplastic lesions of uterine cervix and its correlation with histological type, grade and stage.

Methods: Total 50 cases was included during a period from 2017 to 2018. It was a cross-sectional study including both preneoplastic and neoplastic lesion of uterine cervix, immunohistochemistry for HER 2/neu expression was performed in all the cases.

Results: HER2/neuexpression was seen in 56% cases. Out of 50 cases, 10 was preneoplastic (CIN) and 40 was neoplastic (SCC and adenocarcinoma) lesion. HER2 /neu expression was seen in 3 cases of CIN III, 20 cases of SCC and 5 cases of Adenocarcinoma. Among 35 cases of squamous cell carcinoma, 6 cases were negative for HER2/neu(17%), 9 cases scored 1+(25%), 14 cases 2+(40%) and 6 cases were 3+ (17%). HER2/neu expression was about 50 % in well differentiated SCC, 50% in moderately differentiated and 86 % in poorly differentiated type. Out of 5 cases of adenocarcinoma, HER 2/neu expression was seen in all the cases, of which 3 cases (60%) showed 1+positivity and 2 cases (40%) showed 2+ positivity. 9 cases showed lymph node metastasis positive and out of which 7cases showed HER2/neu positivity (77.77%) and all of them belonged to SCC. Among 14 cases of parametrial extension, 9 cases were positive for HER2 /neu marker. Out of 9 cases 7 cases were of moderately squamous cell carcinoma, 1 was of poorly differentiated SCC and 1 cases of  adenocarcinoma.

Conclusion: This study shows HER 2/neu expression in cervical carcinoma correlates with higher clinical stage. HER 2/ neu expression correlates with lymph node metastasis and with parametrial extensions.

Keywords: Uterine cervix, preneoplastic and neoplastic lesions, Immunohistochemistry, HER 2/neu.

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Corresponding Author

Dr Vijai Singh

Associate Professor, Department of Pathology, Hind Institute of Medical Sciences Barabanki, Uttar Pradesh

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