Title: Clinical and histopathological correlation of ovarian neoplasms: A retrospective study

Authors: Dr Sachin Sharma, Prof. Dr C.V. Kulkarni, Prof. Dr Ashok Yadav, Dr Minakshi Rajput

 DOI: https://dx.doi.org/10.18535/jmscr/v7i3.160

Abstract

Objectives: o study the clinical and histopathological correlation of ovarian neoplasms.  

Material and method: This retrospective study of two year duration from 2016 to 2018 were conducted in pathology department of  Mahatma Gandhi Medical College and  Maharaja Yeshwantrao Hospital, a tertiary care hospital of, Indore (M.P).Total 140 cases with ovarian lesion were studied. Presenting clinical symptoms such as abdominal mass, abdominal pain, menstrual irregularities, weight loss and ascites and related information about age, parity, family history, bilaterality, provisional diagnosis and histopathological analysis were collected from records.

Result: In the present study 140 cases with ovarian lesion were studied out of which non neoplastic lesions were 90 (64.2%) cases and neoplastic were 50 cases (i.e. 35.7%). In neoplastic category majority belongs to benign neoplasm 26/50 (52.0%) then malignant tumors 21/50 (42.5%). Surface epithelial tumours (80%) were common histopathological findings with most of the patient present clinically with abdominal mass in their late reproductive age group(41-60 years).

Conclusion: Ovarian pathology is the widest and most complex problems in modern gynecology mainly through ovarian tumours. There is wide spectrum of clinical and pathological features of ovarian neoplasm. Proper clinical and histopathological correlation of  and categorization according to WHO classification of ovarian neoplasm help in early diagnosis as well as prognosis of ovarian tumors. Histopathological examination remains the gold standard for diagnosing ovarian neoplasms.

Keywords: Ovarian neoplasm, histopathological types.

References

  1. Univ. Dr. Brăila Mihai, Kamal Kamal Constantin, Clinical-Epidemio-logical, Imagistic, Histological And Immunohistochemical Study Of Ovarian Mucinous Tumours University Of Medicine And Pharmacy Craiova.
  2. Adelmen S, benson CD, hertzler JH, surgical lesion of the ovary in infancy & childhood, surggy necolobstate 1975, 141 : 219-222
  3. Gupta N, Bisht D, Agrawal AK, Sharma UK, Comoarative study of ovarian cyst and tumour, J Pak Medical association December 2000,50(12);416-419.
  4. Scully RE, Clement PB, Young RH, Miscellaneous primary tumours, secondary tumours, and non-neoplastic lesions of ovary. In : Mills SE, Carter D, Greenson JK, Oberman HA, Renter V, Stoler MH edts. Sternberg's diagnostic surgical pathology, 4th edn. Philadelphia : Lippincott Williams and Wilkins; 2004.p.2617
  5. Zurawski VR, Jr, Orjaseter H, Andersen A, Jellum E. Elevated serum CA 125 levels prior to diagnosis of ovarian neoplasia: relevance for early detection of ovarian cancer. Int J Cancer. 1988;42:677–680. [PubMed]
  6. Lidor YJ, Xu FJ, Martinez-Maza O, Olt GJ, Marks JR, Berchuck A, et al.Constitutive production of macrophage colony-stimulating factor and interleukin-6 by human ovarian surface epithelial cells. Exp Cell Res.1993;207(2):332–9. doi:10.1006/excr.1993.1200.
  7. Watson JM, Berek JS, Martinez-Maza O. Growth inhibition of ovarian cancer cells induced by antisense IL-6 oligonucleotides. Gynecol Oncol.1993; 49(1):8–15. doi:10.1006/gyno.1993.1077.
  8. Lo CW, Chen MW, Hsiao M, Wang S, Chen CA, Hsiao SM, et al. IL-6 transsignaling in formation and progression of malignant ascites in ovarian cancer. Cancer Res. 2011;71(2):424–34. doi:10.1158/0008-5472.can-10-1496.
  9. Friedman, EL, Hayes, DF, Kufe, DW. Reactivity of monoclonal antibody DF3 with a high molecular weight antigen expressed in human ovarian carcinomas. Cancer Res. 1986;46:5189–5194.
  10. Bast, RC Jr, Knauf, S, Epenetos, A et al, Coordinate elevation of serum markers in ovarian cancer but not in benign disease. Hybridoma. 1987;6:228.
  11. Gruhn JG. A selected historical survey pathology emphasizing neoplasms. In: Roth LM, Czernobilsky B (eds). Tumours and Tumour-like Conditions of the Ovary (Chapter 13). Churchill Livingstone: New York, 1985.
  12. Graham H. Eternal Eve. The History of Gynaecology and Obstetrics. Doubleday and Company, Inc.: New York, 1951.
  13. Pilli GS, Suneeta KP, Dhaded AV, Yenni VV. Ovarian tumours: a study of 282 cases. J Indian Med Assoc2002; 100: 420, 423-4, 447.Morgagni GB. The Seats and Causes of Diseases (English Translation by Benjamin Alexander). Miller A, Cadell T and Johnson and Payne: London,
  14. Ahmad Z, Kayani N, Hasan SH, Muzaffar S, Gill MS. Histological pattern of ovarian neoplasm. J Pak Med Assoc2000; 50: 416-9.
  15. Oumachigui, Narasimhan KL, Reddy KS, et al. A clinicopathologic study of ovarian tumours in children. J Obstet Gynecol. 1991;140:441–5.
  16. Pilli GS, Suneeta KP, Dhaded AV, Yenni VV. Ovarian tumours: a study of 282 cases. J Indian Med Assoc2002; 100: 420, 423-4, 447.
  17. Ahmad Z, Kayani N, Hasan SH, Muzaffar S, Gill MS. Histological pattern of ovarian neoplasm. J Pak Med Assoc2000; 50: 416-9.
  18. Rathi V et al Study Of Histopathological Spectrum Of Ovarian Lesions, Vikram University,Ujjain,2005.
  19. Koonings PP, Campbell K, Mishell DR Jr, Grimes DA. Relative frequency of primary ovarian neoplasms: a10 year review. ObstetGynaecol1989; 74: 921-26
  20. Rafiq B, Kokab H, Rao SI. Ovarian tumours. Professional Med J 2005;12(4):397–403.
  21. R Jha& S Karki , Nepal Medical College,Journal 2008:109(2)81-85.
  22. Levi1 F, Vecchia CL, Randimbison L, Te VC. Borderline ovarian tumours in Vaud. Switzerland: incidence, survival and second neoplasms. Br J Cancer 1999;79(1):4–6
  23. Burkholz KJ, Wood BP, Zuppan C. Best Cases from the AFIP: Borderline papillary serous tumour of the right ovary. Radiographics 2005;25:1689–92.
  24. Outwater EK, Siegelman ES, Kim B, Chiowanich P, Blasbalg R, Kilger A. Ovarian Brenner tumours: MR imaging characteristics. MagnReson Imaging 1998;16:1147–53
  25. Herbst AL. The Epidemiology of Ovarian Carcinoma and the Current Status of Tumour Markers to Detect Disease. Am JObstetGynecol 1994;170:1099–107.
  26. Di Bonito L, Patriarca S, Delendi M, Alberico S. Ovarian tumours: anatomohistopathological contribution to their interpretation. Eur J GynaecolOncol1988; 9: 324-30.
  27. Chakrabortti DK, Lee CMS. Epidemiological study ovarian neoplasms. J Obstetgynaecol India 1990; 40:582 -6.
  28. Greggi S, Parazzini F, Paratore MP, Chatenoud L, Legge F, Mancuso S et al. Risk factors for ovarian cancer in central Italy. GynecolOncol 2000; 79:50-4.
  29. Salazar-Martinez E, Lazeano-Pance EC, Gonzalez Lira-Lira G, Escudero- De Los Rios P, Salmeron-Castro J, Hernandez-Avila M. Cancer Res 1999; 59:3658-62.
  30. Yen ML, Yen BL, Bai CH, Lin RS. Risk factors for ovarian cancer in Taiwan: a case control study in a low incidence population. GynecolOncol 2003; 89: 318-24.
  31. Zhang M, Lee AH, Binns CW. Reproductive and dietary risk factors for epithelial ovarian cancer in China. GynecolOncol 2004; 92: 320-6
  32. KOLWIJICK, E. et al. Preoperative CA-125 level in 123 patients with borderline ovarian tumors: a retrospective analysis and review of the literature. Int J Gynecol Cancer, v. 19, n. 8, p. 1335-8, 2009. [ Links]
  33. OSMAN, N. et al. Correlation of serum CA125 levels with stage, grade and survival of patients with epithelial ovarian cancer. J ClinOncol, v. 25, n.18, suppl. 16006, 2007. [ Links]

Corresponding Author

Minakshi Rajput

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