Title: Psychometric Hepatic Encephalopathy Score for the Detection of Minimal Hepatic Encephalopathy in South Indian patients with Liver Cirrhosis

Authors: Kumaravel Gopal, Pradeep Kumar Mamallan, Dhananjayan Kannan, Suresh Paul Raj Mohan Raj

 DOI: https://dx.doi.org/10.18535/jmscr/v7i3.103

Abstract

Background: MHE is the mild form of spectrum of HE, defined as a mild neurocognitive and psychomotor disorder present in cirrhotic patients. MHE is not recognizable on usual clinical examination, requiring the use of PHES.The objective of this study was to standardize PHES[4] in healthy south Indian population and evaluate the prevalence of MHE among south Indian patients with cirrhosis.

Materials and Methods: This is a case control study done at Kilpauk Medical College. 40 cases diagnosed as cirrhosis admitted there and 40 controls were subjected to PHES testing.

Results: 19 patients (47.5%) with cirrhosis were diagnosed with MHE in present study with PHES score.

Conclusion: PHES study is statistically significant in detecting MHE in cirrhotic patients, and correlates with severity.

Keywords: Encephalopathy, Cirrhosis, Ammonia,Ascites, Bilirubin.

References

  1. Shawcross, D.L.Wright, G.Olde damink, s.w. & jalan.R, systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis .J.Hepatol.40,247-254 [2004]
  2. Karin Weissenborn Diagnosis of subclinical hepatic encephalopathy Med sci Monit,1999; 5 [3]:568-575.
  3. Radha k.dhiman.yogesh K Chawla. Minimal hepatic encephalopathy. Indian J Gastroenterol 2009:18:5 – 16.
  4. .seo ys, yim sy, yung JY, Kim CH. Psychometric hepatic encephalopathy score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis, J, Gastroenterol hepatol 2012 nov; 27[11]:1695-704.
  5. Lockwood AH, Yap EW, Wong WH. Cerebral ammonia metabolism in patients with severe liver disease and minimal HE. J Cereb Blood flow metab 1991; 11:337-341.
  6. Amodio p, Del Piccolo F, Petteno E, et al, prevalence and prognostic value of EEG alterations in cirrhotic patients. J. Hepatol 2001; 35:37-45.

Corresponding Author

Pradeep Kumar Mamallan

Assistant Professor, Department of General Medicine, Government Kilpauk Medical College and Hospital, Chennai – 600010, India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile: 9444833555