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Category: Volume 07 Issue 03 March 2019
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Title: Comparison between the effects of Gum Arabic and Omega 3 Fatty Acids on The Plasma Level of Kidney Injury Molecule-1 and Kidney Functions in an Experimentally-Induced Model of Early Diabetic Nephropathy

Authors: Pr. Patricia Sidrak, Pr. Hala M. Maklad, Dr Nesrine M. El Azhary, Amalkhaer M. Khalifa

 DOI: https://dx.doi.org/10.18535/jmscr/v7i3.93

Abstract

Diabetic nephropathy (DN) is one of the most common devastating complication of diabetes mellitus. Several studies tried to find drugs that could hinder it or prevent it. The current study aims to compare between the effects of Gum Arabic and Omega-3 fatty acids administration on the plasma level of kidney injury molecule (KIM -1) and kidney functions in an experimentally induced model of early diabetic nephropathy in rats.

Methods: Forty male albino rats were randomly assigned to four groups (n= 10 each): Group I (healthy control), group II (untreated diabetic control), group III (diabetic rats that received Gum arabic in a dose of 7.5 g/kg/day for 3 weeks) and group IV (diabetic rats that received Omega-3 fatty acids in a dose of 400 mg/kg/day for3 weeks after diagnosis of diabetes mellitus).

Results: Gum Arabic supplementation significantly decreased KIM-1, fasting blood glucose, proteinuria in the second and third week and improved creatinine clearance when compared to untreated diabetic rats. On the other hand, Omega-3 FA supplementation significantly decreased proteinuria in the second and third weeks compared to untreated diabetic group but it did not show significant effects on the other parameters.

Conclusion: GA is beneficial and may hinder the development of early diabetic nephropathy.

Keywords: Kidney injury molecule-1, Experimentally induced diabetes mellitus, Diabetic nephropathy, Kidney functions, Gum Arabic, Omega-3 fatty acids, Streptozotocin.

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Corresponding Author

Pr. Patricia Sidrak

Department of Medical Physiology, Faculty of Medicine, Alexandria University, Egypt