Details
Category: Volume 07 Issue 03 March 2019
Hits: 1435

Title: A Study of Neonatal Convulsions with Special Reference to Levels of Magnesium and Incidence of Hypomagnesemia in Hypocalcemic Neonates

Authors: Dr Sravan Kumar Kusuma, Dr Attada Ajay Kumar, Dr Jagadeeswararao Metta

 DOI: https://dx.doi.org/10.18535/jmscr/v7i3.33

Abstract

Introduction: Neonatal seizure is a common neurological problem in the neonatal period. Neonatal seizures have always been a topic of interest because of its universal occurrence. A varied number of conditions are capable of causing seizures in the neonatal period the highest incidence of neonatal seizures occurs during first 24hrs of life. Neonatal seizures often signal an underlying ominous neurological condition, most commonly hypoxic ischemia. The other common etiologies of neonatal seizures are intra-ventricular hemorrhage or intra-parenchymal hemorrhage, meningitis, sepsis or metabolic disorders.

Aims and Objectives

  • To study the etiology of neonatal seizures.
  • To evaluate neonatal seizures with reference to biochemical changes with special reference to serum magnesium levels.
  • Microbiological investigation to find the most common organisms implicated in neonatal seizures

Patients and Methods: All the babies with neonatal seizures who were admitted in department of Paediatrics between July 2017 and August 2018 were studied

Results: The incidence of seizures is most common in during first 24hrs of life. Perinatal Asphyxia is the most common cause of neonatal seizures followed by ICH. Among the Biochemical abnormalities hypoglycemia is the most common cause for neonatal seizures followed by hypocalcemia Of 150 cases meningitis accounts for 18 cases for which most common organism was E.Coli.

References

  1. Saliba RM, Annegers JF, Waller DK, Tyson JE, Mirzahi EM, 1999, incidence of neonatal seizures in harris county, Texas, 1992-1994. American journal of epidemiology 150: 763-769.
  2. Sheth RD, Hobbs GR, Mullett M 1999, neonatal seizures: incidence , onset and etiology by gestational age, journal of perinatology 19: 40-43
  3. Weiner SP, Painter NJ, Geva D, Guthrie RD, Scher MS 1991, neonatal seizures: electroclinical dissociation. Paediatric neurology7: 363-368.
  4. Meharban Singh, Care of the Newborn 2015; 8;123-130
  5. AIIMS Protocols seizures in newborn, 2008; 149-159
  6. Volpe JJ Neonatal seizures in neurology of newborn, Philadelphia, WB. Saunders 1999: 172-225
  7. Siegel MJ, Shackelford GD, Perlman JM, Fulling KH, Hypoxic Ischemic Encephalopathy in term infants, Diagnosis prognosis evaluated by ultrasound. Radiology 1984; 394-400
  8. Babecock DS, Ball W, Post asphyxia encephalopathy in fullterm infants US diagnosis Radiology 1993: 417-423
  9. Wical BS, Neonatal seizures Electrographic analysis, evaluation of outcome, pediatric, newyork, 1994: 10: 271-275
  10. Mizrahi annals of neurology Neonatal seizures, problems in diagnosis and classification, 42: 318-325
  11. Mizrahi eli M, Neonatal seizures and neonatal epileptic syndromes, neurologic clinics in epilepsy 2001; 19(2): 427-456.
  12. Meharban singh, care of the newborn, Neurological disorders, 2015; 8: 435-441.
  13. Fenichel, Clinical pediatric neurology, signs and symptoms, approach…
  14. Janet Rennie; Rennie & Roberton’s Textbook of Neonatology, 2012; 5
  15. Mary L. Zupana, MD, Neonatal seizures; Pediatric clinics 2004; 51: 961-978
  16. Christine A. Gleason, MD, Sherin Devaskar, MD; Avery’s Diseases of the Newborn, 2012, 9: 901-919
  17. MC Cabe BK, Silveira DC, Cilio M R et al 2001 Reduced neurogenesis after neonatal seizures, Journal of neuroscience 6: 2094-2103
  18. .Kleigman, Stanton, St. Geme, Schor, Berhman, Nelson textbook of paediatrics, 20 th edition;volume 3: 2849-2854.
  19. Digra K.S, Gupta A. Prevalence of seizures in hospital neonates: JK Science 2007; 9(1): 2729.
  20. Holden KR, Mellites ED, Freeman JM, Neonatal seizures, correlation of prenatal and perinatal events with outcome. Paediatrics 1982; 70: 165-176.
  21. Airede I.K. Neonatal seizures and a 2 year neurological outcome, J Trop Pediatr 1991; 37: 313-317
  22. Cloherty, John P, Eichenwald, Eric C, Stark, Ann R Stark manual of neonatal care, 6: 729-742
  23. .Neonatal seizures Volpe JJ eds., Neurology of the newborn 4th edition, Philadelphia: W.B. Saunders, 2001: 178-216.
  24. Curtis PD Matthews TG Clarke T et al 1988 neonatal seizures Archives of the diseases in childhood 63: 1065-1067. Ronnen GM, Penny S Andrews W 1999 The epidemiology of clinical neonatal seizures in Newfoundland; a population based study, Journal of paediatrics 134: 71-75.
  25. Goldberg HJ. Neonatal convulsions – a 10 year review. Arch Dis child 1983;976-978
  26. Alistair GS, Allan C.W, Intraventricular hemorrhage in preterm infants: declining incidence in the 1980’s paediatrics 1989; 84(5): 797-801
  27. Arvind Sood Neelam Grover and Roshan Sharma. Biochemical abnormalities in neonatal seizures Indian Journal of Pediatrics 2003; 70: 221-224
  28. Bergman I, Painter MJ, Hirsch RP, Crumin PK, David R 1983. Outcome in neonates with convulsions treated in ICU. Annals of neurology 14; 642-667
  29. Ortibus EL, Sum JM, Hahn JS 1996. Predictive value of EEG for outcome and epilepsy following neonatal seizures. Electroencephalography and clinical neurophysiology 98; 175-185
  30. Bernes SM, Kaplan AM, Evaluation of Neonatal seizures, PCNA 1994; 41: 1069-1102
  31. Goldberg HJ 1982 Neonatal convulsions- a ten year review , archives of diseases in children 57: 633-635
  32. Ronnen GM, Penny S 1995, the epidemiology of clinical neonatal seizures in Newfoundland, Canada: a 5year cohort, Annals of neurology 38; 518-519
  33. Andre M, Matisse M, Vert P, DFebruille C 1998, Neonatal seizures- recent aspects, neuropediatrics 19:202-207.

Corresponding Author

Dr Sravan Kumar Kusuma

Postgraduate, Department of Pediatrics, Andhra Medical College