Title: Neonatal hypoglycaemia: Risk factors and clinical profile

Authors: Dr Rafiq Anjum, Dr Rashid Anjum, Dr Shazia Qayum

 DOI: https://dx.doi.org/10.18535/jmscr/v7i2.189

Abstract

Aim: To evaluate various maternal and fetal risk factors for neonatal hypoglycemia and its clinical presentation.

Introduction: Neonatal hypoglycemia is one of common metabolic problem specifically in the existence of risk factors for hypoglycemia. Symptoms of hypoglycaemia vary from lethargy, jitteriness, apnea, irritability, to seizures or may be absolutely asymptomatic. The hypoglycaemia with symptoms is usually associated with poor neurodevelopmental consequences.

Methods: This prospective study included 100 neonates born in Neonatal department of a tertiary hospital of Northern India, from 1st January 2017 to 31 December 2017.Detailed history about demographic characteristics of the mothers and their children was obtained. All the risk factors and clinical features were documented.

Results: Spectrum of clinical presentation included temperature instability 39%, jitteriness 34%, lethargy in 32%, cyanosis 12%, tachypnea 8%, apnoea 6% and seizures 9%. Maternal risk factors for neonatal hypoglycaemia noticed were maternal diabetic mellitus in 38%, eclampsia 22%, use of drugs like beta blockers (15%), oral hypoglycemic agents (08%), valproate (07%), by mother and family history of metabolic disorder (09%). (Table no.3). Neonatal risk factors were noticed as: hypothermia 22%, endocrine disorder 7%, inborn errors of metabolism 3%, inadequate feeding 32%, low birth weight 48%, small for gestational age 29%, respiratory distress 31% and sepsis 20% .

Conclusion: The common risk factors associated with neonatal hypoglycemia are low birth weight, small gestational age, respiratory distress, sepsis, hypothermia and inadequate feeding and maternal risk factors associated to neonatal hypoglycaemia were maternal diabetes, eclampsia, and maternal drug use.

Keywords: Hypoglycemia, neonates, low birth weight, maternal diabetes mellitus.

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Corresponding Author

Dr Shazia Qayum

House no.209, Dhanore  Jarallan, Rajouri, J&K., India

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