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Category: Volume 07 Issue 02 February 2019
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Title: Treatment of taxane acute pain syndrome (TAPS) in cancer patients received taxane-based chemotherapy. A prospective randomized study done at State Cancer Institute J&K.

Authors: Fir Afroz,  Dar Abdul Waheed, Najmi Arshad Manzoor, Malik Tariq Rasool, Wani Shaqul Qamar, Saba Sumera, Gupta Parul, Dar Ishtiyaq Ahmad, Matoo Omer Farooq

 DOI: https://dx.doi.org/10.18535/jmscr/v7i2.184

Abstract

Objectives: The main aims of this study is to describe the incidence and for both prevention and treatment of TAPS.

Methods: The Study was a prospective one in which we included Eligible patients scheduled to receive paclitaxel, nab paclitaxel or docetaxel either weekly or 3 weekly alone or combination with other chemotherapy. Patient-reported outcome for acute pain were collected and evaluated. Outcome measures of interest included the type of treatment for TAPS, as well as the response of myalgias, arthralgias, pain, and quality of life using Mc Gill Quality of life questionnaires. All those Patients who developed pain, were analyzed for response corticosteroid, gabapantine or duloxitine.

Results: A total of 80 patients were available for the analysis, of which 32 patients (40%) received paclitaxel and carboplatin, while as 30 patients (37.5%) received paclitaxel alone, 10 patients (12.5%)  received nab paclitaxel and 8 patients (10%) received docetaxel. Among them 54 developed TAPS, comparing with corticosteroid, 30 Patients (55.5%) responded taxene induced pain by corticosteroid, 7 patients (12 percent) responded to gabapantin and 17 patients (31%) responded to duloxitine.

Conclusion: The present study has expanded the use of taxanes to numerous cancers. A larger number of patients are, at risk of taxane-induced pain syndrome. Possible strategies to decrease the incidence of pain syndrome include by addition of the medica­tions, have been evaluated to reduce the incidence of TAPS. However, no therapy has been consistently successful; conventional analgesics are also inconclusive.

More studies should be performed to identify these characteristics as well as patients at risk for the develop­ment of taxane-induced myalgia and arthralgia, thereby allowing a risk-adapted strategy of medical prevention.

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Corresponding Author

Dar Abdul Waheed