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Category: Volume 07 Issue 02 February 2019
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Title: Prevalence of asymptomatic hyper-uricemia in adult patients attending a peripheral community health centre of Kashmir

Authors: Dr Rouf Hussain Rather, Dr Aadil Bashir Rather, Dr Umar Nazir

 DOI: https://dx.doi.org/10.18535/jmscr/v7i2.136

Abstract

Introduction: Hyperuricemia is usually defined as a serum urate (SU) level >7mg/dL in men and >6mg/dL in women. Its prevalence is around 15-18% in general population. Hyper-uricemic patients are usually classified as overproducers (10%) and as under excretors caused due to inefficient excretion by the kidneys (90%).

Objectives: To estimate the prevalence of asymptomatic hyper-uricemia and non-communicable diseases in adult patients visiting a peripheral Community Health centre in Kashmir. Methodology: This study was conducted in a peripheral Community health centre of Kashmir valley. The study was carried out over 6 months in adult patients of 18yrs or more visiting to hospital for any aliment other than symptomatic hyper-uricemia. A total of 1050 patients were included in the study which included 425 men and 625 women.

Results and Observation: The prevalence of hyper-uricemia was 30.1% in men and 15.7% in women. The mean age of the study subjects was 44.7 in males and 41.5 yrs in females. Hypertension was present in 25.4% of men and 24.5% of women, diabetes in 7.5% of men and 11.4% of women of the total study group. History of smoking was present in 40% of men and 0.3% of women and hypothyroidism in 7.8% of men and 9.5% of women.

Conclusion: Hyper-uricemia is very frequent in Kashmir valley with men outnumbering women. This high prevalence could be related to genetics and high red meat consumption. Hyper-uricemia has high correlation with the various components of the metabolic syndrome. Considering this association more emphasis should be put on hyper-uricemia.

Keywords: Qazigund, Hyper-Uricemia, Overproducers.

References

  1. Mikuls TR, Farrar JT, Bilker WB, et al.The treatment of asymptomatic hyperuricemia: results from the population-based general practice research database (GPRD). Arthritis Rheum. 2003;48(suppl 9):S612.
  2. Rott KT, Agudelo CA.JAMA. 2003;289:2857-2860.
  3. Meigs JB, Wilson PW, Nathan DM, D’Agostino RB Sr, Williams K, Haffner SM.Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring Studies. Diabetes. 2003;52:2160-2167.
  4. Ford ES, Giles WH, Dietz WH.Prevalence of the metabolic syndrome among US adults: findings from the Third National Health and Nutrition Examination Survey. JAMA. 2002;287:356-359.
  5. Campion EW, Glynn RJ, DeLabry LO.Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study. Am J Med. 1987;82:421-426.
  6. Langford HG, Blaufox MD, Borhani NO, et al.Is thiazide-produced uric acid elevation harmful? Analysis of data from the Hypertension Detection and Follow-up Program. Arch Intern Med. 1987;147:645-649.
  7. Hall AP, Barry PE, Dawber TR, McNamara PM.Epidemiology of gout and hyperuricemia. A long-term population study. Am J Med. 1967;42:27-37.
  8. Fessel WJ.Renal outcomes of gout and hyperuricemia. Am J Med. 1979;67:74-82.
  9. Johnson RJ, Feig DI, Herrera-Acosta J, Kang DH.Resurrection of uric acid as a causal risk factor in essential hypertension Hypertension. 2005;45:18-20.
  10. Savage PJ, Pressel SL, Curb JD, Schron EB, Applegate WB, Black HR, Cohen J, Davis BR, Frost P, Smith W, Gonzalez N, Guthrie GP, Oberman A, Rutan, Probstfiel JL, Stamler J: Influence of long-term, low-dose, diuretic-based, antihypertensive therapy on glucose, lipid, uric acid, and potassium levels in older men and women with isolated systolic hypertension. Arch Int Med.1998,158:741-751. 10.1001/archinte.158.7.741.View ArticleGoogle Scholar
  11. Fang J, Alderman MH: Serum uric acid and cardiovascular mortality. The NHANES I epidemiologic follow-up study, 1971–1992. JAMA. 2000, 283: 2404-2410. 10.1001/jama.283.18.2404.View Article PubMed Google Scholar
  12. Mikkelsen WM, Dodge HJ, Valkenburg H: The distribution of serum uric acid values in a population unselected as to gout or hyperuricemia. Am J Med. 1965, 39: 242-251. 10.1016/0002-9343(65)90048-3.View Article PubMed Google Scholar
  13. Freedman DS, Williamson DF, Gunter EW, Byers T: Relation of serum uric acid to mortality and ischemic heart disease. The NHANES I epidemiologic follow-up study. Am J Epidemiol. 1995, 141: 637-644.PubMedGoogle Scholar
  14. Gordon T, Kannel WB: Drinking and its relation to smoking, blood pressure, blood lipids, and uric acid. The Framingham Study. Arch Int Med. 1983, 143: 1366-1374. 10.1001/archinte.143.7.1366.View ArticleGoogle Scholar
  15. Vuorinen-Markkola H, Yki-Järvinen H: Hyperuricemia and insulin resistance. J Clin Endocrinol Metab. 1994, 78: 25-29. 10.1210/jc.78.1.25.PubMed Google Scholar
  16. Facchini F, Ida Chen Y-D, Hollenbeck CB, Reaven GM: Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance and plasma uric acid concentration. JAMA. 1991, 266: 3008-3011. 10.1001/jama.266.21.3008.View ArticlePubMedGoogle Scholar.
  17. Bengtsson C: Elevated serum uric acid levels during treatment with antihypertensive drugs. Acta Med Scand Suppl. 1979, 628: 69-71.PubMedGoogle Scholar.
  18. Messerli FH, Froehlich ED, Dreslinski GR, Suarez DH, Aristimuno GG: Serum uric acid in essential hypertension: an indicator of renal vascular involvement. Ann Intern Med. 1980, 93: 817-21.View ArticlePubMedGoogle Scholar.

Corresponding Author

Dr Rouf Hussain Rather

Demonstrator in the Department of Community Medicine, Government Medical College, Karanagar Srinagar, India

Phone number: 7006826153, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.