Title: Evaluation of Daunorubicin as an adjuvant in Trabeculectomy
Authors: Dr Paramjeet Kaur, Dr Archana Gupta and Dr Sarabjit Singh
DOI: https://dx.doi.org/10.18535/jmscr/v7i2.82
Abstract
Purpose of the study is to evaluate the intraocular pressure (IOP) lowering effect and ocular side effects of Daunorubicin (DNR) in drug modulated trabeculectomy.
Method: A prospective study was conducted on 50 eyes of 49 patients. Only primary open angle cases were taken up for the study. These were randomly divided into equal groups. Group I underwent modified trabeculectomy with application of 0.2mg/ml of Daunorubicin (DNR) intra operatively. Group II underwent conventional trabeculectomy, patients were followed for six months. Parameter including visual acuity , IOP by NCT/ shiotz, slit lamp examination were performed on every visit. An IOP of 21mg Hg or less were taken as criteria for success.
Results: 48% of the patients were males and 52% females. The visual acuity was maintained at preoperative levels for all cases except two in which it improved from 6/24 top 6/18 in group I and deteriorated from 6/9 to 6/18 in one patient in group II. The final mean IOP at 24 weeks was 14.23 + 4.94 mm Hg in group I and 16.2 + 5.07 mm Hg in group II. A success rate of 92% (IOP < 20mm Hg) was obtained in S/C Daunorubicin versus 84% in group II at 24 weeks.
Conclusion: These results indicate primary trabeculectomy with Daunorcubicin to be associated with 92% success rate and lower mean IOP levels as compared to those undergoing Primary trabeculectomy without adjuvant Daunorubicin.
Keywords: Trabeculectomy, Daunorubicin, Intraocular Pressure (IOP).
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