Details
Category: Volume 07 Issue 01 January 2019
Hits: 967

Title: Effect of Oxytocin on blood Pressure variation during Normal Delivery in Different Socio-Economic Groups

Authors: Anju Kumari, Anita Kumari, Ashok Sharan, Kamla Sharma, Seema Kumari

 DOI: https://dx.doi.org/10.18535/jmscr/v7i1.198

Abstract

Objectives: Present study was carried out to determine the variation of Blood Pressure (BP) during normal delivery and effect of oxytocin on BP in different socioeconomic groups to help in establishing better perinatal care towards achieving the goal of healthy mother and baby.

Materials and Method: Hundred cases of normal delivery were included in our study. Blood pressure was recorded at the time of admission, at onset of labour, after full dilatation of cervix, after delivery of baby, after Oxytocin injection and during puerperium.

Results:  Upper middle class - Baseline mean Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 117± 5.56 and 77.92 ± 5.63 mmHg respectively. There was significant rise in SBP and DBP at onset of labour (122.76.±4.82 & 82.20± 4.8 mmHg respectively, p <0.05). SBP and DBP fall significantly after oxytocin injection (114.40±6.47 & 75.24±4.98 mmHg).

Lower class - Baseline mean Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 119.32± 6.03 and 78.84 ± 5.35 mmHg respectively. There was significant rise in SBP and DBP at onset of labour (123.84 ±5.34 & 82.94± 5.02 mmHg respectively, p <0.05).  SBP and DBP fall significantly after oxytocin injection (116.68 ± 6.29& 75.08±4.77mmHg).

Conclusion: There is wide variation in BP during normal delivery and it rises significantly at onset of labour and falls significantly after Oxytocin injection. Close monitoring of Blood pressure during normal delivery may result in better perinatal outcome.

Keywords: Normal Delivery, Diastolic Blood Pressure, Oxytocin, Systolic Blood Pressure, Variation.

References

  1. Brown R.C. A study of the Maternal B.P. variations in 50 cases of normal labour with a consideration of the effects of analgesia, Anaesthesia,Vol.6:nos2 April 1951
  2. Duvekot JJ, Cheriex EC, Pieters FA, Menheere PP, Peeters LH. Early pregnancy changes in hemodynamics and volume homeostasis are consecutive adjustments triggered by a primary fall in systemic vascular tone. Am J Obstet Gynecol 1993;169:1382–92.
  3. Hendricks CH, Quilligan EJ. Cardiac output during labor. Am J ObstetGynecol 1956;71:953–72.
  4. Robson SC, Dunlop W, Boys RJ, Hunter S. Cardiac output during labour. Br Med J (Clin Res Ed) 1987;295:1169–72.
  5. Dale HH. The action of extracts of the pituitary body .Biochemistry Journal 1909;4:427–
  6. Du Vigneaud V, Ressler C, Swan JM, Roberts CW, Katsoyannis PG, Gordon S. The synthesis of an octapeptide amide with the hormonal activity of oxytocin. Journal of the American Chemical Society 1954;75(19):4879–80:
  7. Devikarani D, Harsoor SS. Are we using right dose of oxytocin? Indian J Anaesth 2010;54:371-3.
  8. Weis FR Jr, Markello R, Mo B, Bochiechio P. Cardiovascular effects of oxytocin.  Obstet Gynecol 1975;46:211–14
  9. Why Mothers Die 1977–1999. The confidential enquiries into maternal deaths in the United Kingdom. London: RCOG Press,2001
  10. M.Edwards, The blood pressure in normal labour,June 1958; 65:367–370
  11. Anjlimaroo, Prgnancy and Heart Disease, page no.816
  12. Cohen et al. European Journal of Obstetrics &Gynecology and Reproductive Biology 184 (2015) 103–107.
  13. Gandhi, M.M Malde, A., Kudalkar, A. & Karnik, H. (2011). A Practical Approach to Anesthesia for Emergency Surgery. Jaypee Brothers Publishers, New Delhi, India.
  14. Steer, P. et al (2006). Heart Disease and Pregnancy. The Royal College of Obstetricians and Gynaecologists. Henry Ling Ltd, Dorchester, UK. Section 5: Intrapartum Care. PP 285 – 294.
  15. Sodre, P.M.(2010). Obstetrics & Gynecology: Maternal Physiology Changes During Pregnancy. Retrieved June 2014 from: http://www.medstudents.com.br/ginob/ginob5.htm
  16. Anderson & Etches (2007). Prevention and Management of Postpartum Hemorrhage. American Family Physician. Retrieved June 2014 from: http://www.aafp.org/afp/2007/0315/p875.html
  17. Davies GA, Tessier JL, Woodman MC, Lipson A,Hahn PM. Maternal hemody-namics after oxytocin bolus compared with infusion in the third stage of labor: a randomized controlled trial.Obstetrics &Gynecology2011;105 (2):294-9
  18. Cotter AM, Ness A, Tolosa JE. Prophylactic oxytocin for the third stage of labour. Cochrane Database of Systematic Review 2001, Issue 4.[DOI:10.1002/14651858.CD001808]

Corresponding Author

Dr Anita Kumari

Tutor, Dept of Physiology Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Phone: 7004536074