Title: A study to evaluate the short term prognostic significance of HsCRP in acute coronary syndrome during hospital stay

Authors: Dr Saurabh Singh Tomar, Dr Manisha Chauhan

 DOI: https://dx.doi.org/10.18535/jmscr/v7i1.185

Abstract

Introduction: The present study was designed to evaluate the serum concentration  of  HsCRP  in  acute  coronary syndrome, its association with subsequent consequences to assess the short term
prognostic significance.

Objective: To evaluate the short term prognostic significance of HsCRP in acute coronary syndrome during hospital stay.

Methodology: Study Design: Case Control Observational Study.

Study Duration: 21 July 2017 to 21 March 2018.

Results: The prognosis of the patient with acute coronary syndrome depends upon the elevated value of HsCRP.

Conclusion: Very high HsCRP level, a potent independent predictor of poor prognosis in patients with acute myocardial infarction.

References

  1. Srinath Reddy K, Shah B, Varghese C, Ramadoss A: Responding to the threat  of  chronic  diseases  in    Lancet 2005, 366(9498):1744-9.
  2. Peter Libby   Treatment   and   prevention   of   atherosclerosis Harrison’s Principles of Internal Medicine 16th Edition Kasper, Braunwald, Fauci, Hauser, Longo, Jameson. McGraw Hill 2005.
  3. Lalchandani A, Dig Vijay T , Saxena SK et al. Blood levels of Myeloperoxidase, Creactive protein and Troponin I as prognostic marker   in   acute   coronary      Indian   Heart   J 2005;57:411.
  4. Liuzzo, L.M. Biasucci, J.R. Gallimore, Grillo R L, Rebuzzi A.G, Pepys M.B., Maseri A, The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med 331 (1994), pp. 417-424.
  5. Honarmand H, Mirzajani E, Rahbar-Taromsari M, Saadat F et The relationship and diagnostic value of CRP and HsCRP for myocardial infarction, African Journal of Microbiology, 2011; 5 : 3215-3219
  6. Lindahl, H. Toss, A. Siegbahn, P. Venge and L. Wallentin, Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. FRISC Study Group:  Fragmin  during  instability  in  coronary  artery disease. N Engl J Med 343 (2000), pp. 1139-1147.
  7. Ramon Arroy, Espliguero et al. C-reactive protein evaluation and disease activity in patients with coronary artery disease. Europian Heart Journal, 2004;25: 401-408.
  8. Benjamin M  Scirica  et  al.  Clinical  application  of  C-reactive  protein  across  the  spectrum  of  acute  coronary  syndromes. Clinical Chemistry, 2007; 53: pg1800-1807.

Corresponding Author

Dr Manisha Chauhan (M.S. Obstetrics & Gynaecology)