Title: Significance of Bone Marrow Aspiration in Hematological Disorders
Authors: Dr Shailesh Kumar Pankaj, Dr Om Prakash Dwivedy
DOI: https://dx.doi.org/10.18535/jmscr/v7i1.183
Abstract
Aims and Objective: Hematological disorders are quite frequent in all age group. Most of this hematological disorder first present as anemia. Bone Marrow Aspiration plays a major role in the diagnosis of its underlying cause. The aim of this study was to analyze the spectrum of hematological disorders.
Materials and Methods: This was carried out prospective study of Bone marrow examination of 130 cases in suspected case of hematological disorders. All details of the patients were obtained from the record file in the department of pathology of our hospital.
Results: Among the malignant hematological disorders, Acute Myeloid Leukemia (AML) was the most common disorders 12(9.23%) followed by CML 8 (6.15%), CLL 5 (3.85),ALL 3(2.31) and MDS 2(2.31%). Among the non-malignant hematological disorders, Megaloblastic anemia 35(26.92%), Iron deficiency Anemia 17(13.08%), Dimorphic Anemia 28(21.54%), Bone marrow Hypoplasia 8(6.15%) and ITP 3(2.31%).
Conclusion: Bone marrow examination is an important step to arrive at the confirmatory diagnosis of many hematological disorders.
Keywords: Bone marrow examination, Non- malignant hematological disorder and Malignant hematological disorder.
References
- Dacie JV, Lewis SM. Practical hematology. 8th edition. ELBS.Chapter 10; p. 175-190.
- Young NS, Abkowitz JL, Luzzatto L. New Insights into the Pathophysiology of Acquired Cytopenias. Hematology 2000;18-38.
- Omal IK, Sumer H, Tufan A, Shorbagi A. Bone marrow embolism after marrow aspiration and biopsy. Am J Hematol.2005;78(2):158.
- Rahim F, Ahmad I, Islam S, Hussain M, Khattak TAK, Bano Q.Spectrum of hematological disorders in children observed in 424 consecutive bone marrow aspirations/biopsies. Pakistan Journal of Medical Sciences 2005;21 (4):433-436.
- Pudasaini S, Prasad KBR, Raniyar SK, Shrestha R, Gautam K, Pathak R, et al. Interpretation of bone marrow aspiration in hematological disorder. Journal of Pathology of Nepal, 2012; Vol.-2: 309-312.
- Lab Test on Line @ 2001 - 2012, by American association for clinical chemistry.
- Gaynon PS, Bostrom BC, Hutchinson RJ. Duration of hospitalization as a measure of cost on Children’s Cancer Group acute lymphoblastic leukemia studies. J Clin Oncol. 2001; 19:1916-25.
- Mussarat N, Raziq F. The incidence of underlying pathology in pancytopenia. An experience of 89 cases. J Postgr Med Inst. 2004;18(1):76-9.