Abstract

Introduction

The radicular cyst (periapical cyst) is the common cyst of odontogenic origin. Most commonly the cause of radicular cyst is an infected or a non-vital tooth with pulpal necrosis. The toxins leave the apical end of the tooth which leads to periapical inflammation. The periapical inflammation in turn stimulates the rest of malassez present in the apical periodontal ligament leading to a formation of periapical granuloma. In due course this epithelium undergoes necrosis due to lack of blood supply and the granuloma transforms into a cyst (periapical cyst). Usually the lesions when small are clinically asymptomatic and are discovered as clinical or radiologic findings during regular dental check up.

Platelet rich fibrin as described by choukron et al¹ is a second generation platelet concentrate which contains platelets and growth factors in the form of fibrin membranes prepared from the patient’s own blood free of any anticoagulant or other artificial biochemical modifications^1,2. Autologous PRF is said to have healing capabilities as a biomaterial and presently studies have been conducted which show its application in various disciplines of dentistry and oral and maxillofacial surgery.

After activation of platelets which are trapped in the fibrin matrix, growth factors are released and stimulate the mitogenic response in the bone periosteum during normal wound healing for repair of the bone³

PRF represent a new revolutionary step in platelet gel therapeutic concept ⁴. The platelets and leukocyte cytokines play an important role in the this biomaterial, and the fibrin matrix supporting this is very helpful in determining the element responsible for the healing ⁵