Title: Study the relationship between hs-CRP level and urinary albumin creatinine ratio (UACR) levels

Authors: Kheta Ram Sharma, Vikas, R P Agrawal, Anil Khatri, Ramesh Rathore

 DOI: https://dx.doi.org/10.18535/jmscr/v7i1.80

Abstract

 

Background: C-reactive protein (CRP), an acute phase reactant, is a highly sensitive marker of inflammation. Its level rises dramatically during an inflammatory process. CRP has a long half life, affordability of estimation and stability of its levels with no circadian variation and therefore is one of the best markers of vascular inflammation.

Methods: Hospital based cross-sectional  Study was conducted at Department of Medicine, S.P. Medical College, Bikaner on Type 2 diabetes patients reporting to OPD & IPD of Medicine Department.

Results: Mean hs-CRP in UACR group <30 µg/mg was 1.76±1.37 mg/l and in >30 µg/mg it was 6.12±3.36 mg/l and this difference was found statistically highly significant (p<0.001).

Conclusion: We found hs-CRP is high in microalbuminuria group compared to normoalbuminuria group. It was also found in our study that diabetic nephropathy is associated with hs-CRP level.

Keywords: C-reactive protein (CRP),  Inflammation, Urinary albumin creatinine ratio (UACR).

References

  1. Rivero A, Mora C, Muros M, García J, Herrera H, Navarro-González JF. Pathogenic perspectives for the role of inflammation in diabetic nephropathy. Clin Sci 2009; 116(6): 479–492.
  2. Hasegawa G, Nakano K, Kondo M. Role of TNF and IL-1 in the development of diabetic nephropathy. Nefrologia 1995; 15:1-4.
  3. Mahajan A, Tabassum R, Chavali S, Dwivedi OP, Bharadwaj M, Tand on N, et al. High­sensitivity C­reactive protein levels and type 2 diabetes in urban North Indians. J Clin Endocrinol Metab. 2009; 94:2123–7.
  4. Martha RM, Fernando GR. Increased levels of CRP in non­controlled type II diabetic subjects. J Diabetes Complications. 1999; 13:211–5.
  5. Navarro JF, Mora C, Maca M, Garca J. Inflammatory parameters are independently associated with urinary albumin in type 2 diabetes mellitus. Am J Kidney Dis. 2003; 42(1):53-61.
  6. Saraheimo M, Teppo AM, Forsblom C, Fagerudd J, Groop PH. Diabetic nephropathy is associated with low-grade inflammation in Type 1 diabetic patients. Diabetologia 2003;46:1402–1407.

Corresponding Author

Vikas

Resident Doctor, Department of Medicine, S.P. Medical College & A.G. of Hospitals, Bikaner, India