Title: Clinical investigative profile of Neonatal septicaemia and outcome at tertiary care rural hospital
Author: Aatif Sattar
DOI: https://dx.doi.org/10.18535/jmscr/v7i1.70
Abstract
Background: Neonatal septicaemia remains one of the leading causes of morbidity and mortality both among term and preterm infants. signs and symptoms of neonatal sepsis are nonspecific.[3] These include fever or hypothermia, respiratory distress including cyanosis and apnoea, feeding difficulties, lethargy or irritability, hypotonia, seizures, bulging fontanel, poor perfusion, bleeding problems, abdominal distention, hepatomegaly, gauiac-positive stools, unexplained jaundice Neonatal sepsis is of two types: Early onset Sepsis (EOS): Early onset sepsis presents within first 72 hours of life Late onset Sepsis (LOS): Late onset sepsis commonly presents next 72 hours of age. The cause of infection is either one nosocomial or community acquired and neonates typically existent with septicaemia, pneumonia or meningitis.
Aim: Clinical investigative profile of Neonatal septicaemia and outcome at tertiary care rural hospital.
Objective: to study the various clinical features of neonatal septicaemia for its early identification, to study the result of various investigation in identification of early and late onset neonatal septicaemia to identify various factor leading to neonatal septicaemia.
Material and Methods: A prospective and observational study was carried out Pravara institute of Medical Sciences, which is located at Loni.
Study Population: A total of 130 febrile subjects aged up to 28 days with clinical features such as Babies with birth asphyxia and congenital anomalies were excluded from the study.
Observation and Result: The most common symptoms seen were lethargy and refusal of feeds in 61.66% and 55.9% respectively, followed by apnoea and respiratory distress in 34.17% and 21.67% respectively. Vancomycin and colistin showed 100% efficacy against Gram-positive isolates while amikacin, meropenem and linezolid was found to be most effective among Gram-negative isolates in both EOS and LOS.
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