Title: Intravenous Haloperidol Induced Atrial Fibrillation: A Case Report
Authors: Dr Madhumita Preetam Rauth, Dr Sanjiv S. Kale
DOI: https://dx.doi.org/10.18535/jmscr/v7i1.04
Abstract
Antipsychotic drugs are known to cause adverse cardiovascular effects such as postural hypertension, tachycardia and arrhythmias. Haloperidol is one of the antipsychotic drugs and is having adverse cardiovascular effects. This case report highlights the cardiac risk associated with use of Haloperidol, particularly if used parenterally and in elderly.
Keywords: Haloperidol, Atrial fibrillation, Antipsychotic Drug,
References
- Sigma Pharmaceuticals Pty Ltd. Product Monograph. 2003.
- Gerlach J, Korsgaard S. Classification of abnormal involuntary movements in psychiatric patients. Neuropsychiatr Clin 1983;2:201-208.
- Y.T. Leung et al. Cardiovascular side-effects of antipsychotic drugs: The role of the autonomic nervous system. Pharmacology & Therapeutics 135 (2012) 113-122
- Suessbrich et al. The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium Jm channels expressed in Xenopus oocytes. British journal of Pharmacology 120 (1997) 968-974
- Froemming JS, Lam YW, Jann MW, Davis CM. Pharmacokinetics of haloperidol. Clin Pharmacokinet 1989;17:396-423.
- Hennessy S, Bilker WB, Knauss JS, et al. Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data. BMJ 2002;325:1070.
- Wayne A. Ray et al. Antipsychotics and the risk of Sudden Cardiac Death. Arch Gen Psychiatry Vol 58, Dec 2001