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Category: Volume 06 Issue 12 December 2018
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Title: Resistance to Commonly Used Antimicrobial Agents in Bacterial Pathogens Isolated from Urinary Tract Infections in tertiary care teaching hospital

Authors: Suren Kumar Das, Swayam Prabha Sahoo, Debabrata Kumar Sabat

 DOI: https://dx.doi.org/10.18535/jmscr/v6i12.189

Abstract

The point of this examination was to get information on powerlessness examples of pathogens in charge of both network and healing center urinary tract contaminations (UTIs); and broke down hazard factors for disease caused by ciprofloxacin-safe Escherichia coli and expanded range β-lactamace (ESBL)- creating strains in Bhubaneswar, Odisha. Of 1,012 pee societies tentatively examined, a sum of 196 (19.3%) yielded noteworthy development of a solitary life form. The most well-known segregate (60.7%) was Escherichia coli . The anti-infection agents regularly utilized in UTIs are less compelling with the exception of Fosfomycin-trometamol and imipinem. The utilization of ciprofloxacin in the past a half year (chances proportion [OR] = 7.59 [1.75– 32.74]), utilization of different anti-toxins in the past a half year (OR = 1.02 [1.02– 2.34]), and creation of ESBL (OR = 19.32 [2.62– 142.16]) were observed to be related with ciprofloxacin obstruction among the E. coli disengages. Hazard factors for ESBL inspiration were the utilization of ciprofloxacin and third-age cephalosporin in the former a half year (OR = 3.05 [1.42– 6.58] or potentially = 9.78 [2.71– 35.25], individually); and being an inpatient (OR = 2.27 [1.79– 2.89]). Fosfomycin-trometamol could be incorporated as a sensible option for the treatment of uncomplicated UTI in Bhubaneswar, Odisha.

References

  1. Ronald AR, Pattulo MS. The natural history of urinary infection in adults. Med Clin North Am 1991; 75:299-312.
  2. Liperky BA. Urinary tract infection in men: epidemiology, pathophysiology, diagnosis and treatment. Ann Intern Med 1989; 111:138-50.
  3. New CH. Urinary tract infection. Am J Med 1992 (suppl); 4A: 63-70.
  4. Gebre-Selassie S. Asymptomatic bacteriuria in pregnancy: epidemiological, clinical and microbiological approach. Ethiop Med J 1998; 36:185-92.
  5. Pastore LM, Savitz DA, Thorp JM Jr, et al. Predictors of symptomatic urinary tract infection after 20 weeksʼ gestation. J Perinatol 1999; 19:488-93.
  6. Tambyah PA, Maki DG. Catheter associated urinary tract infection is rarely symptomatic; a prospective study of 1497 catheterized patients. Arch Int Med 2000; 160:678-82.
  7. Van Nostrand JD, Junkins AD, Bartholdi RK. Poor predictive ability of urinalysis and microscopic examination to detect urinary tract infection. Am J Clin Pathol 2000; 113:709-13.
  8. Srinivasa H, Parija SC, Bhattacharya S, Sehgal R. Incidence of ciprofloxacin resistance in urinary isolates Eastern Nepal. J Comm Dis 1999; 31:45-7.
  9. Navaneeth BV, Belwadi S, Suganthi N. Urinary pathogensʼ resistance to common antibiotics: a retrospective analysis. Trop Doct 2002; 32:20-2.
  10. Iqbal J, Rahman M, Kabir MS, Rahman M. Increasing ciprofloxacin resistance among prevalent urinary tract bacterial isolates in Bangladesh. Jpn J Med Sci Biol 1997; 50:241-50.
  11. Clinical and Laboratory Standards Institute , 2008. Performance Standards for Antimic-robial Susceptibility Testing: Eighteenth Informational Supplement 100-S18. Wayne, PA : Clinical and Laboratory Standards Institute .
  12. Raka L , Mulliqi-Osmani G , Berisha L , Begolli L , Omeragiq S , Parsons L , Salfinger M , Jaka A , Kurti A , Jakupi X , 2004 . Etiology and susceptibility of urinary tract isolates in Kosova . Int J Antimicrob Agents 23 (Suppl 1): S2 – S5 .
  13. Randrianirina F , Soares JL , Carod JF , Ratsima E , Thonnier V , Combe P , Grosjean P , Talarmin A , 2007 . Antimicrobial resistance among uropathogens that cause community-acquired urinary tract infections in Antananarivo, Madagascar . J Antimicrob Chemother 59: 309 – 312 .
  14. Akram M , Shahid M , Khan AU , 2007 . Etiology and antibiotic resistance patterns of community-acquired urinary tract infections in J N M C Hospital Aligarh, India . Ann Clin Microbiol Antimicrob 6: 4 .
  15. Andrade SS , Sader HS , Jones RN , Pereira AS , Pignatari AC , Gales AC , 2006 . Increased resistance to first-line agents among bacterial pathogens isolated from urinary tract infections in Latin America: time for local guidelines? Mem Inst Oswaldo Cruz 101: 741 – 748 .
  16. Schaeffer AJ , Rajan N , Cao Q , Anderson BE , Pruden DL , Sensibar J , Duncan JL , 2001 .Host pathogenesis in urinary tract infections . Int J Antimicrob Agents 17: 245 – 251.
  17. Hryniewicz K , Szczypa K , Sulikowska A, Jankowski K , Betlejewska K , Hryniewicz W ,2001 . Antibiotic susceptibility of bacterial strains isolated from urinary tract infections in Poland. J Antimicrob Chemother 47: 773 – 780.
  18. Arslan H, Azap OK , Ergonul O , Timurkaynak F , 2005 . Risk factors for ciprofloxacin resistance among Escherichia coli strains isolated from community-acquired urinary tract infections in Turkey . J Antimicrob Chemother 56: 914 – 918 .
  19. Karlowsky JA , Kelly LJ , Thornsberry C , Jones ME , Sahm DF , 2002 . Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States . Antimicrob Agents Chemother 46: 2540 – 2545.
  20. Aboderin OA , Abdu AR , Odetoyin BW , Lamikanra A , 2009 . Antimicrobial resistance in Escherichia coli strains from urinary tract infections . J Natl Med Assoc 101: 1268 – 1273 .
  21. Goettsch W , van Pelt W , Nagelkerke N, Hendrix MG , Buiting AG , Petit PL , Sabbe LJ , van Griethuysen AJ , de Neeling AJ, 2000. Increasing resistance to fluoroquinolones in Escherichia coli from urinary tract infections in The Netherlands . J Antimicrob Chemother 46: 223 – 228 .
  22. Hooton TM , 2003 . Fluoroquinolones and resistance in the treatment of uncomplicated urinary tract infection. Int J Antimicrob Agents 22 (Suppl 2): 65 – 72.
  23. Schito GC, 2003. Why fosfomycin trometamol as first line therapy for uncomplicated UTI? Int J Antimicrob Agents 22 (Suppl 2): 79 – 83 .
  24. Ullah F, Malik SA , Ahmed J , 2009 . Antimicrobial susceptibility and ESBL prevalence in Pseudomonas aeruginosa

Corresponding Author

Dr Debabrata Kumar Sabat

Associate Professor, Dept of Urology, IMS and SUM Hospital, Bhubaneswar, 751003, Odisha, India

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