Title: A comparative study of two marketed preparations of Vitamin D for safety and efficacy in Vitamin D deficient children
Authors: Dr Yashwant Gabhale, Dr Savita Khadse, Dr Sujata Sharma, Dr Harshada Uchil, Dr Rohan Videkar
DOI: https://dx.doi.org/10.18535/jmscr/v6i12.157
Abstract
Aim and Objectives: The present study was undertaken to compare the safety and efficacy of two Vitamin D syrups in normalizing various biochemical markers of Vitamin D deficiency in children.
Method: 79 children of either sex, aged between 8 to 15 years were enrolled in the study. They were divided into two groups to receive either one of the two marketed formulations of Vitamin D3. 36 patients were treated with Uprise D3 [Syrup (A)] and 43 patients were treated with Deksel nano syrup (B). Both formulations containing 60,000 IU of Cholecalciferol were administered once a week for 10 weeks. The change in 25(OH) D levels from baseline was recorded at 6 weeks and 12 weeks.
Results: Both the formulations have shown a significant rise in 25(OH) D levels but the rise with Syrup B was significantly higher than that seen with Syrup A over baseline, at week 6 and week 12. Treatment with either of the formulations was able to reduce the elevated alkaline phosphatase levels both at 6 and 12 weeks. But in neither of the case reduction from the baseline was significant. Serum calcium and serum phosphorus levels remained unaltered after either of the treatment, both at 6 and 12 weeks. Significant reduction in elevated parathyroid hormone levels was seen only with Deksel nano syrup. This was observed as early as 6 weeks of initiating treatment.
Conclusion: Deksel nano syrup is a better formulation as it was shown to produce consistently higher rise in 25(OH) D levels. The formulation also demonstrated a trend towards normalization of elevated parathyroid hormone levels.
Keywords: Vitamin D, Uprise D3 Syrup, Deksel nano syrup, Cholecalciferol, Alkaline phosphatase, Parathyroid hormone.
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