Details
Category: Volume 06 Issue 12 December 2018
Hits: 1129

Title: Incidence and trend of Carcinoma Lung among women and use of oral TKI – A Single Institution Based Study

Authors: Dr Suparna Ghosh (Ray), Dr Suranjan Maitra

 DOI: https://dx.doi.org/10.18535/jmscr/v6i12.52

Abstract

Lung cancer is the most common cancer of men in India, whereas it is 2nd most common in women in India as per Globocon 18 data. Smoking tobacco is the principal risk factor for causation of lung cancer. However causation of carcinoma lung in women is not clearly defined. In the present observational study we have investigated the causal risk factors of carcinoma lung among female patients especially below 60 years of age group. As part of management, trend of usage of Tyrosine Kinase Inhibitor (oral TKI) in female lung cancer patients was also investigated, with outcome. There is lack of epidemiological data on Lung cancer among women from India as well as outcome of Oral Tyrosine kinase inhibitor (TKI) or Epidermal growth factor receptor inhibitor (EGFR) in female carcinoma lung.

Keywords: India, Lung cancer, oral Tyrosine kinase inhibitor (TKI), Epidermal growth factor receptor (EGFR).

References

  1. World Health Organization. The Global burden of Disease. 2004 update Geneva. World Health Organization, 2008.
  2. Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C. and Parkin, D. M. (2010), Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer, 127:2893-2917. doi:10.1002/ijc.25516
  3. Krishnamurthy A, Vijayalakshmi R, Gadigi V, Ranganathan R, Sagar T G. The relevance of "Nonsmoking-associated lung cancer" in India: A single-centre experience. Indian J Cancer 2012;49:82-8. doi:10.4103/0019-509X.98928
  4. ZhongL ,Goldberg MS,Parent ME.Hanley JA.Lung Cancer 2000Jan;27(1):3-18.PMID 10672729.
  5. Gupta D, Baffatta P, GaborieauV Jindal. Int Journal of Pharma & Biosciences2015 April ;6(2):(P) 450-457.
  6. Jong Myon Bae, Eun Hu Kim. Epidemiol Health 2015; Nov17;37 e 2015052.
  7. Malik P S, Sharma M C, Mohanti B K, Shukla N K, Deo S, Mohan A et al. Clinicopathological profile of lung cancer at AIIMS.A changing paradigm in India. Asian PAC J Cancer Review.2013;14:489-494.
  8. Dey A, Biswas D, Saha S K, Kundu S, Kundu S, SenGupta A.; Comparison study of clinicoradiological profile of primary lung cancer cases. An Eastern India Experience. Indian J Cancer 2012;49:89-95
  9. A Mohan, AN Latiffi,, R.Gulleria: Increasing incidence of Adenocarcinoma Lung in India. Following the global trend.2016 April; vol 53,issue 1;92-95.
  10. Li Han Heu, NeiMin Chu,Shu Huein. Estrogen ,estrogen receptor and lung cancer .International journal of Mol Science 2017.August(8):1713.
  11. Noronha V, Prabhash K, Thavamani A, Chougule A, Purandare N, JoshiA et al. EGFR mutation in Indian lung cancer patients. Clinical correlation and outcome to EGFR targeted therapy.PLoS one.2013;8:e61561.
  12. Thatcher N,Chang A, Parikh P,Rodrigues Pereira J, Ciuleanu T,Von Pawel J, Thongprasert S, Tan EH, pemberton K.Archer V, CarrroliK .Lancet 2005.Oct 29 –Nov 4;366 (9496):1527-37.
  13. Shi Y, Au J S, Thongprasert S, Srinivasan S, Tsai C M, Khoa M T et al. A prospective molecular epidemiology study of EGFR mutation in Asian patients with advanced non small cell lung  cancer of adenocarcinoma histology (PIONEER) J Thoracic Oncol.2014;9:154-62.
  14. Prescott E,Osler M,Hein HO,Boren Johnsen K,Lange P,Schnohr P et al.Gender and smoking related risk of Lung carcinoma.The Copenhagen centre for prospective population study .Epidemiology 01. 1998;9(1):79-83.
  15. Khuder SA, Mulgi AB. Effect of smoking cessation on HPE types of lung cancer .Chest 2001: Nov;120(5): 1577-83
  16. Yano T, Haro A, Shikada Y, Maruyama R, Maehara Y. Non small cell Ca in never smoker as a representative “Non smoking associated lung ca –epidemiology & clinical features.
  17. Shaw A T, Kim D W, Nakagawa K, Seto T, Crino L, Ahn M J et al .Crizotinib versus chemotherapy in advanced ALK positive lung cancer. NEngl J Med,2013;368:2385-94.
  18. Sahoo R, Harini V V, Babu V C, Patil Oklay, GV Rao S, Nargund A et al. Screening for EGFR mutations in lung cancer, A report from India Lung Cancer 2011;73:316-9.
  19. Doval D, Provas K, Patil S, Chaturvedi H, Goswami C, Vaid A et al Clinical and epidemiological study of EGFR mutation and EML4-ALK fusion genes among Indian patients with Adenocarcinoma of the Lung, Onco Targets Ther 2015;8:117-23

Corresponding Author

Dr Suranjan Maitra

RMO-Clinical Tutor, Radiation Oncology

Department of Radiotherapy, Calcutta National Medical College & Hospital

24.Gorachand Road Kolkata. Pin code-700014, West Bengal, India