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Category: Volume 06 Issue 12 December 2018
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Title: Use of Meter Dose Inhaler (MDI) Corticosteroid Therapy, May Cause Tuberculosis, in Patients with Bronchial Asthma

Authors: Dr Gaurav Tiwari, Dr Deepak Kumar, Dr Satyendra Pathak

 DOI: https://dx.doi.org/10.18535/jmscr/v6i12.23

Abstract

Objective: The aim of present study was to evaluate the incidence and pattern of tuberculosis in Bronchial asthma patients receiving inhalational corticosteroid therapy by MDI.

Materials and Method: A total of 76 patients taking MDI steroid for bronchial asthma, and 76 patients suffering from the similar disease but not receiving MDI steroids serves as a control, were included in the study and evaluate  for the incidence and pattern of tuberculosis. All the patients were followed up for 18 months.

Results: Out of 76 patients, 4 patients (5.26%) receiving MDI steroid developed tuberculosis as against patients not receiving MDI steroid, out of 4 patients, who developed tuberculosis, one developed sputum smear positive pulmonary disease, one had sputum smear negative disease and two had extra pulmonary tuberculosis in the form of pleural effusion and tubercular lymphadenitis one each. All patients were treated with standard anti tuberculous therapy using RNTCP guidelines and all patients recovered from the disease.

Conclusion: Inhalational corticosteroid in the form of MDI causes a significant increase in incidence of tuberculosis.

Keywords: Tuberculosis, Bronchial asthma, MDI, pleural effusion, Incidence.

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Corresponding Author

Dr Gaurav Tiwari

Tutor, Department of Pharmacology, Sri Krishna Medical College, Muzaffarpur, India