Title: Study of Thyroid Disorders in Women with AUB in A Medial College in Rural Area of Jabalpur (M.P.)
Authors: Dr Sakshi Mishra, Dr Rohit Chaturvedi
DOI: https://dx.doi.org/10.18535/jmscr/v6i11.121
Abstract
Background: Thyroid gland is one of the most important vital endocrine gland and is essential for growth, development, metabolism and function of almost all organs of our body.. Thyroid dysfunctions both hypothyroidism and hyperthyroidism can lead to menstrual disturbances and infertility. AUB is one of the most common clinical presentation in gynaec OPD, prevalence being 10-20% of women from puberty to menopause. This study is aimed at detecting thyroid dysfunction in patients with provisional diagnosis of AUB
Methods: This study was conducted in the Department of Obstetrics & Gynecology, Sukh sagar medical college & Hospital, Jabalpur. 140 women presented with AUB presenting to gynec OPD were recruited in the study. After taking Complete history of all recruited a thorough general physical examination along with pelvic examination was carried out. Basic routine investigations and T3, T4, TSH was performed by in all patients.
Results: In AUB cases 24.2% were diagnosed with thyroid disorder of which subclinical hypothyroidism was most common .Most common presentation of AUB was menorrhagia (41.4%) . Thyroid dysfunction with AUB was commonest in age group of ≥45 years (33%). Most common presentation being menorrhagia in all age groups except 35-45 years, where Oligo/hypomenorrhoea was more common.
Conclusions: Both subclinical hypothyroid and p hypothyroid cases together were the commonest thyroid dysfunction and menorrhagia was their commonest menstrual abnormality. So this study concludes that, biochemical evaluation of thyroid functioning should be made mandatory in all provisionally diagnosed cases of DUB to detect thyroid dysfunction.
Keywords: Thyroid dysfunction, Hypothyroidism, Subclinical hypothyroidism, Hyperthyroidism, Menstrual disorders.
References
- Olive D, Palter S. Reproductive physiology. In: Berek JS, eds. Berek and Novak’s Gynaecology. 14th ed. Philadelphia: Lippincott Williams and Wilkins Company; 2002:161-86.
- Poppe K, Glinoer D. Thyroid autoimmunity and hypothyroidism before and during pregnancy. Human Reprod Update.2003;9:149–61.
- Kochupillai N. Clinical endocrinology in India. Curr Sci. 2000;79:
- Hollowell JG, Staehling NW, Flanders WD. Serum TSH, T4 and thyroid antibodies in the United States population (1988 to 1994): National health and nutrition examination survey (NHANES III). J Clin Endocrinol Metab. 2002;87(2):489-99.
- Bals-Pratsch M, Geyter D, Muller C, et al. Episodic variations of prolactin, thyroid-stimulating hormone, luteinizing hormone, melatonin and cortisol in infertile women with subclinical hypothyroidism. Human Reprod. 1997;12:896–904.
- Abraham R, Murugan VS, Pukazhvanthen P, et al. Thyroid disorders in women of puducherry. Indian J Clin Biochem 2009;24(1):52–9.
- Steiner RA, Fink D. Abnormal menstrual bleeding. Schweiz Rundsch Med Prax. 2002;91:1967-74.
- Vinita S, Ashwini SN. Impact of thyroid disorders on menstrual function. Fogsi Focus. 2006;1:30-1.
- Devi J, Aziz N. Study of histopathological pattern of endometrium in abnormal uterine bleeding in the age group 40-60 years. A study of 500 cases. Int J Med Sci Clinic Invent. 2014;1:579-85.
- John Thompson, Jeferey Warshaw. Hysterectomy. In: John Rock, eds. Te Linde’s Operative Gynecology. 8th ed. Philadelphia: Lippincott Williams and Wilkins Company; 1997: 771-854.
- Narula ER; Menstrual Irregularities. J Obstet Gynecol India. 1967;17:164.
- Pahwa S, Gupta S, Kumar J. Thyroid dysfunction in dysfunctional uterine bleeding. J Adv Res Biol Sci. 2013;5(1):78-83.
- Pilli GS, Sethi B, Dhaded AV, Mathur PR. Dysfunctional uterine bleeding. J Obstet Gynecol India. 2001;52(3):87-9.
- Ashok Kumar H. S, Saravanan S. A study of prevalence of thyroid disorders in patients with abnormal uterine bleeding International Journal of Reproduction, Contraception, Obstetrics and Gynecology Int J Reprod Contracept Obstet Gynecol. 2017 Mar;6(3):1036-1039.
- Prasad Yeshwant Deshmukh1, B. G. Boricha, Ankita Pandey.The association of thyroid disorders with abnormal uterine bleeding International Journal of Reproduction, Contraception, Obstetrics and Gynecology . Int J Reprod Contracept Obstet Gynecol. 2015 Jun;4(3):701-708.