Title: Asymptomatic Gallstones: Dilemma, Controversy and Consensus

Authors: Rajiv Ranjan, Kishore Kumar Sinha, Mahesh Chaudhary

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i11.80

Abstract

Background: Cholecystectomy is currently advised only for patients with symptomatic gallstones. However, about 4.1% of patients with asymptomatic gallstones develop symptoms including cholecystitis, obstructive jaundice, pancreatitis, and gallbladder cancer.

Objectives: To assess the benefits and harms of surgical removal of the gallbladder for patients with asymptomatic gallstones.

Material & Methods: A topic wise search was done in Pubmed, Google-scholar, medIND and other electronic sources for asymptomatic gallstone, silent gallstones and preventive cholecystectomy.

Conclusion: There are no randomized trials comparing cholecystectomy versus no cholecystectomy in patients with silent gallstones. Further evaluation of observational studies, which measure outcomes such as obstructive jaundice, gallstone-associated pancreatitis, and/or gall-bladder cancer for sufficient duration of follow-up, is necessary.

But Laparoscopic cholecystectomy may be recommended for asymptomatic gallstones in areas where there is high prevalence of gallbladder stone disease and cancer.

Keywords: Asymptomatic gallstone, silent gallstones, preventive cholecystectomy, AsGS, gallbladder carcinoma.

References

  1. Prevalence of gallstone disease in an Italian adult female population. Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO), Capocaccia-L, Giunchi-G, Pocchiari-F, et-al. American Journal of Epidemiology1984, 119/5 (796-805). Pubmed-Medline.
  2. NIH Consensus Statement. Gallstones and laparoscopic cholecystectomy. NIH Consensus Statements 1992. 10: No.3.
  3. American College of Physicians guidelines for the treatment of gallstones. Ann Intern Med 1993;119:620-2
  4. Bragg LE, Thompson JS (1989) Concomitant cholecystectomy for asymptomatic cholelithiasis. Arch Surg 124:460–462
  5. Khuroo MS, Mahajan R, Zargar SA, Javid G, Sapru S. Prevalence of biliary tract disease in India: a sonographic study in adult population in Kashmir. Gut 1989; 30:201-5.
  6. Singh V, Trikha B, Nain C, Singh K, Bose S. Epidemiology of gallstone disease in Chandigarh: a community-based study. J Gastroenterology Hepatol 2001;16:560-3
  7. Behari A, Kapoor VK (2010) Does gallbladder cancer divide India? Indian J Gastroenterol 29(1):9–13
  8. Dutta U, Nagi B, Garg PK, Sinha SK, Singh K, Tandon RK. Patients with gallstones develop gallbladder cancer at an earlier age. Eur J Cancer Prev 2005;14:381-5
  9. Sen U, Sankaranarayanan R, Mandal S, Ramanakumar AV, Parkin DM, Siddiqi M. Cancer patterns in eastern India: the first report of the Kolkata cancer registry. Int J Cancer 2002;100:86-91.
  10. Nandakumar A, Gupta PC, Gangadharan P, Visweswara RN, Parkin DM. Geographic pathology revisited: development of an atlas of cancer in India. Int J Cancer 2005;116:740­-54.
  11. Bhurgri Y, Bhurgri A, Hassan SH, Zaid SHM, Rahim A, Sankaranarayanan R, Parkin DM. Cancer incidence in Karachi, Pakistan: first results from Karachi cancer registry. Int JCancer 2000;85:325-9.
  12. Dhir V, Mohandas KM. Epidemiology of digestive tract cancers in India IV. Gall bladder and pancreas. Indian J Gastroenterol 1999;18:24-8
  13. Batra Y, Pal S, Dutta U, Desai P, Garg PK, Makharia G, et al. Gallbladder cancer in India: a dismal picture. J Gastroenterol Hepatol 2005;20:309-14.
  14. Randi G, Franceschi S, La Vecchia C. Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer 2006;118:1591-602.
  15. Lazcano-Ponce EC, Miquel JF, Muñoz N, Herrero R, Ferrecio C, Wistuba II, et al. Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin 2001;51:349-64.
  16. Gracie WA, Ransohoff DF. The natural history of silent gallstones: the innocent gallstone is not a myth. N Engl J Med 1982;307:798-800.
  17. Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO). Prevalence of gallstone disease in an Italian adult female population. Am J Epidemiol 1984;119:796-805.
  18. NIH Consensus Statement. Gallstones and laparoscopic cholecystectomy. NIH Consensus Statements 1992. 10: No.3
  19. American College of Physicians guidelines for the treatment of gallstones. Ann Intern Med 1993;119:620-2.
  20. Angelico F, Del Ben M, Barbato A, Conti R, Urbinati G. Ten-year incidence and natural history of gallstone disease in a rural population of women in central Italy. The Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO). Ital J Gastroenterol Hepatol 1997;29:249­-54.
  21. Halldestam I, Enell EL, Kullman E, Borch K. Development of symptoms and complications in individuals with asymptomatic gallstones. Br J Surg 2004;91:734-8.
  22. Puschel K, Sullivan S, Montero J, Thompson B, Diaz A. Cost-effectiveness analysis of a preventive program for gallbladder disease in Chile. Rev Med Chile 2002;130:447­-59
  23. Nande AG, Shrikhande SV, Rathod V, Adyanthaya K, Shrikhande VN. Modified technique of gasless laparoscopic cholecystectomy in a developing country: a 5-year experience. Dig Surg 2002;19:366-72.
  24. Kaushik R, Sharma R, Batra R, Yadav TD, Attri AK, Kaushik SP. Laraoscopic cholecystectomy: an Indian experience of 1233 cases. J Laparoendosc Adv Surg Teach A 2002;12:21-5
  25. Mathur A V . Need for Prophylactic Cholecystectomy in Silent Gall Stones in North India . Indian J Surg Oncol (September 2015) 6(3):251–255
  26. Gurusamy KS, Samraj K (2007) Cholecystectomy versus no cholecystectomy in patients with silent gallstones. Cochrane Database Syst Rev (1):CD006230.

Corresponding Author

Rajiv Ranjan

Senior Resident, Department of Surgery, A.N.M.M. College Hospital, Gaya, Bihar, India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.