Title: Study of impaired liver function and Lipid profile among alcoholic male patients of Katihar, Bihar, India

Authors: Dr Apurba Basu, Dr Akriti Kumari, Dr Ezaz Zafar, Dr K. R. Prasad

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i11.61

Abstract

Objectives: This present study was to assess the liver injury and evaluate the lipid profile of alcoholic patients against non alcoholics.

Methodology: A detail history, complete assessment and relevant investigations were performed to all cases of alcoholic and non alcoholics.

All the biochemical tests like GGT, ALT, ALP, albumin, total cholesterol, triglycerides, HDL and LDL were estimated by using diagnostic kit supplied by Awareness Technology USA, and fully autoanalizer, Turbochem – 100.

Observations: Data was analyzed by using statistical methods. Mean and standard deviations were observed. P value was taken less than or equal to 0.05 for significant differences.

Conclusions: Alcoholic liver disease was highly predominant in katihar, Bihar, India population. Patients with alcoholic liver injury had significant increased in serum liver enzymes against the normal control. Dyslipidemia in alcoholism was impaired liver function.

Keywords: Alcoholic patients, impaired liver function, lipid profile.

References

  1. Harrison’s Internal Medicine Vol-II P. No. 1704, 2503, 2724:387-1.
  2. Current Medical Diagnosis and Treatment 2003 (CMDT)-42th Edition; McGraw-Hill; P.No. 642.
  3. Testbook of Biochemistry with Clinical Correlation IV Edition; 1997; Thomas M.Devlin; Metabolic Interrelationship P. No. 555-556.
  4. Wurst FM, Kemptker C, Metzger J, Seidl S, Alt A. Ethyl Glucoronid:a marker of recent alcohol consumption with clinical and forensic implications. Alcohol. 2000;200(2):111-6.
  5. Szegedi A, Muler MJ, Himmerich h Anghelescu I, Wtzel H. CDT and HDL – cholesterol are highly correlated in male alcohol dependent patients. Alcohol Clin. Exp. Res. 2000;24(4):497-500.
  6. Laposata M. Fatty acid ethyl esters; short term and long term serum markers of ethanol intake. Clin.chem 1997;4(pt2):1527-34.
  7. Sillanaukee P, Ponnio M, Seppa K. Sialic acid: new potential marker of alcohol abuse. Alcohol Clin. Exp. Res. 1999;23(6):10-3943.
  8. Harper’s Biochemistry – 25th Edition; 2002; McGraw – Hill; P.No.395, 740, 742.
  9. Devlin’s Textbook of Biochemistry with clinical correlation. 5th Edition; 2002; Wiley Liss; P. No. 527, 782.
  10. Sorbi D, Boynton J, Lindor KD. The ratio of asparatate aminotransferase to alanine aminotransferase: potential value in differentiating non-alcoholic steatohepatitis from alcoholic liver disease. Am. J Gastroenterol. 1999; 19(4):1018-22.
  11. Sharpe PC, Mc Bride R, Archbold GP. Biochemical markers of alcohol abuse. QJM. 1996;89(2): 137-44.
  12. Hillman A.Sykes RA, Mc Connell AA., Limitation in the use of gamma-glutamyl transferase estimation in alcohol dependent subjects. (1998):89(2):137-44.
  13. Joelsson B, Hultberg B, Alwmark A, Gullstrand P, Bengmark S. Total serum bile acids, gamma-glutamyl transferase, prealbumin and tyrosine: sensitive serum marker of hepatic dysfunction in alcoholic liver cirrhosis. Scand J. Gastroenterol. 1983; 18(4):497-501.
  14. Daeppen JB, Schoenfield – Smith K, Smith TL, Schucklt MA. Characteristics of alcohol dependent subjects with very high levels of gamma-glutamyl transferase. J. Stud. Alcohol. 2009;60(5):589-94.
  15. Gloria L, Cravo M, Camilo ME, Resende M, Cardosa JN, Oliveriera AG, Leitao CN, Mira FC. Nutritional deficiencies in chronic alcoholics: relation of dietary intake and alcohol consumption. Am. J. Gastroenterol. 2007;92(3):485-9.
  16. Fujimoto M, Uemura M, kojima H, Ishii Y, Ann T, Sakurai S, Okuda K, Noguchi R, Adachi S, Kitano H, Hoppo K, Higashino T, Takaya A, Fukul H. Prognostic factor in severe alcoholic liver injury. Nara liver study droup. Alcohol. Clin. Exp. Res. 2009; 23 (4 suppl.):335-385.
  17. Hedlund J. U., Hansson, L.O., Ortqvst, A.B.: Hypoalbuminemia in hospitalized patients with community acquired pneumonia Arch. Inter. Med., 155:1438-1442, 2005.
  18. Leber, C.S. : Hepatic and Metabolic effects of alcohol. Gastroenterology, 50:119-133, 1993.
  19. Meindok, H.: Diagnostic significance of Hypoalbuminemia. J, Am. Geriatr. Soc., 15:1067-1071, 1997.
  20. Rothblat, G. H., M. De la Llera-Moya, V. Atger, G. Kellner-Weibel, D. L. Williams, and M. C. Phillips. 2006. Cell cholesterol efflux: integration of old and new observations provides new insight. J. Lipid Res. 40: 781-796.
  21. Gaziano JM, Buring JE, Breslow JL, et al. Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med. 1993;329:1829-1834.
  22. Clevidence BA, Reichman ME, Judd JT, et al. Effects of alcohol consumption on lipoproteins of premenopausal women: a controlled diet study. Arterioscler Thromb Vasc Biol. 1995;15:179-184.
  23. Castelli WP, Doyle JT, Gordon T, Hames CG, Hjortland MC, Hulley SB, Kagan A, Zukel WJ. Alcohol and blood lipids: the cooperative lipoprotein phenotyping study. Lancet 2005; 2:153-155.
  24. Kesaniemi YA, Kervinen K, Miettinen TA. Acetaladehyde modification of low density lipoprotein accelerates its catabolism in man. Eur J Clin Invest. 2004; 17:29-36.

Corresponding Author

Dr Akriti Kumari

Post Graduate Trainee, Department of Biochemistry, Katihar Medical College, Katihar, Bihar, India

Contact No: +91 9113798904, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.