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Category: Volume 06 Issue 11 November 2018
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Title: The Association of Serum Vitamin D and Calcium Levels with Early Recurrent Spontaneous Pregnancy Loss

Authors: Prof. Dr Maysoon Shareif, F.I.C.M.S., C.A.B.O.G., A.R.O.C.G, Dr Shaymaa Mahmood K.,M.B.Ch.B., Dr Nawal Hadi Al-Abassy, M.B.Ch.B. D.O.G.

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i11.48

Abstract

Objective: To study the associated between the serum level of vitamin D and calcium among women with early pregnancy loss.

Study Design: This is a prospective study which is conducted in Basrah Maternity and Child Hospital. The study involved 280 women who were divided into 4 groups: 70 pregnant women with healthy pregnancy in the first group, 70 pregnant women with early unhealthy pregnancy in the second group, further, 70 with non-pregnant women with no pregnancy loss in the third group and then the fourth group included  70 women with non-pregnant women with history of pregnancy loss. Plasma was collected from 280 women and serum 25(OH)D and calcium level were estimated and compared between the groups.

Results: Serum 25(OH)D levels for the 4 groups were measured as (45.73±2 ng/ml) in group 1, (20.2±1.4 ng/ml) in group 2, (37.6±2.1 ng/ml) in group 3 and (11.5 ± 3.1 ng/ml) in group 4. There was a clear correlation between low 25(OH)D levels as well as low calcium level and early pregnancy loss.

Conclusion: Vitamin D has a significant role during pregnancy from early implantation and decidualization phase till late pregnancy. Vitamin D deficiency related to poor obstetric outcome. Many studies proved that Vitamin D supplement improved outcome. So, routine screening and supplementation of vitamin D in early pregnancy especially during first trimester are recommended.

Keywords: Calcium, Miscarriage, Pregnancy, Vitamin D.

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Corresponding Author

Prof. Maysoon Sharief

Central Post Office-42001, P. O. Box 1565 Ashar, Basrah, Iraq

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