Abstract
Introduction: Age related hearing loss (ARHL) is a common troublesome disorder of inner ear in elderly. It is characterized by degenerative changes in hair cells leading to slow, insidious, progressive hearing loss. Deficiency of multivitamin & minerals are common in elderly and has been advocated in etiopathology of ARHL.
Aim & Objective: To compare serum vitamin B12 & folic acid in cases of age related hearing loss with normal population.
Materials & Methods: In this prospective study through audiometric assessment was done of 80 patients of ARHL & 80 normal subjects aged 40-60 years. All patients underwent blood estimation of Hemoglobin, BSL, Serum vitamin B12, Folic acid. Data analysis was done by SPSS software.
Results: It was found that serum folic acid was significantly low (P=0.03) in ARHL group as compared to normal subjects. On the other hand, serum vitamin B12 levels showed no statistical difference among both ARHL and control group.
Conclusion: This study indicates low level of serum folic acid is associated with ARHL.
Keywords: Presbyacusis, Multivitamins, Vitamin B12 , Folic acid , SNHL.
References
- Bureau of the Census, US Department of Commerce, Economics and Statistics Administration. Statistical Abstract of the United States, 114th ed. Washington, DC: US Government Printing Office,1994.
- Houston DK, Johnson MA, Nozza RJ, Gunter EW, Shea KJ, Cutler GM, et al. Age-related hearing loss, vitamin B-12, and folate in elderly women. Am J Clin Nutr. 1999;69:564-71. [PMID: 10075346]
- Andres R, Hallfrisch J. Nutrient intake recommendations needed for the older American. J Am Diet Assoc 1989;89:1739–41.
- Ubbink JB , Vermaak WJH, Van der Merwe A , Becker PJ. VitaminB12 ,vitamin B6, and folate nutritional status in men with hyperhomocysteinemia .Am J Clin Nutr 1993; 57:47-53.
- David M Baguley, Evan Reid, Andrew McCombe .Age related sensorineural hearing loss. Scott-Brown’s Otolarhinolaryngology, Head and Neck Surgery 2008; Hodder Arnold 7th edition; 2(238a) :3539-47
- Stanely A Gelfend. Essentials of Audiology. 2nd New York: Thieme ;2001
- Celil Gocer, Umut Genc, Adil Eryilmaz, Ahmet Islam, Suleyman Boynuegri, Fatih Bakir. Homocysteine, Folate and Votamin B12 concentration in Middle Aged Adults Presenting with Sensorineural Hearing Impairment. Int Adv Otol. 2009;5(3) 340-344.
- Savage DG, Lindenbaum J. Folate-cobalamin In: Bailey LB, ed. Folate in health and disease. New York: Marcel Dekker, 1995:237–86.
- Bamini Gopinath, Victoria Flood, Elena Rochtchina, Catherine McMahon, Paul Mitchell. Serum Homocysteine and Folate concentration are associated with prevalent Age related hearing loss.J.Nutr.2010;140:1469-74
- Gates GA, Cobb JL, D’Agostino RB, Wolf PA. The relation of hearing in the elderly to the presence of cardiovascular disease and cardiovascular risk actors. Arch Otolaryngol Head Neck Surg. 1993;119:156-61.
- Berner B, Odum L, Parving A. Age-Related Hearing Impairment and B Vitamin Status. Acta Otolaryngol 2000; 120: 633-7
- Roman GC. An epidemic in Cuba of optic neuropathy, sensorineural deafness, peripheral sensory neuropathy and dorsolateral myeloneuropathy. J Neurol Sci 1994;127:11–28
- Shemesh Z, Attias J, Ornan M, Shapira N, Shahar A. Vitamin B12 deficiency in patients with chronic-tinnitus and noise-induced hearing loss. Am J Otolaryngol 1993;14:94–9.
- Agamanolis DP, Chester EM, Victor M, Kark JA, Hines JD, Harris JW. Neuropathology of experimental vitamin B12 deficiency in monkeys. Neurology 1976;26:905–14.
- Krumholz A, Weiss H, Goldstein P, Harris K. Evoked responses invitamin B12 deficiency. Ann Neurol 1981;9:407–9.
- Fine E, Hallett M. Neurophysiological study of subacute combined degeneration. J Neurol Sci 1980;45:331–6.
- Fine E, Soria E, Paroski M, Petryk D, Thomasula L. The neurophysiologicalprofile of vitamin B12 deficiency. Muscle Nerve 1990;13:158–64.
- Josef Shargorodsky, Sharon Curhan, Roland Eavey, Gary Curhan. A prospective study of vitamin intake and the risk of hearing loss in men. Otolaryngol Head Neck Surg 2010 Feb;142(2):231-6.
Corresponding Author
Dr Maitri Kaushik
DOI: https://dx.doi.org/10.18535/jmscr/v6i10.226
