Title: A Study on Dyslipidemia and the Atherogenic Index of Plasma in Chronic Kidney Disease

Authors: Srividhya.S, Sindhu, Anny Antony

 DOI: https://dx.doi.org/10.18535/jmscr/v6i10.216

Abstract

The purpose of the study is to study and analyse the atherogenicity of plasma in patients with Chronic Kidney Disease. This study was conducted on 85 patients of CKD admitted in Kanyakumari Government Medical College of age more than 18 years with renal function tests and ultrasound findings suggestive of CKD. The mean atherogenic index among CKD patients is .75 in our study. There is a significant change in the mean value of total cholestrol, TGL, and VLDL cholestrol among patients in various stages of CKD.  A significant negative correlation was observed between eGFR and mean Atherogenic Index of Plasma.

Keywords:  Atherogenic index of plasma (AIP), Chronic kidney disease-(CKD), Glomerular filtration rate - (GFR).

References

  1. Lipid Work Group. KDIGO Clinical Practice Guideline for Lipid Management in chronic kidney disease. Kidney Inter., suppl. 2013; 3: 259 – 305.
  2. KDIGO 2012. Clinical Practice Guidelines for the evaluation and management of chronic kidney disease. Volume – 3.Issue – 1. Jan 2013.
  3. Shabnam Niroumand et al. Atherogenic Index of Plasma (AIP): A marker of cardiovascular Disease. Medical journal of  Islamic Republic of Iran. July 2015.
  4. Dobiášová M, Frohlich J, Šedová M, Cheung MC, Brown BG. Cholesterol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography. J Lipid Res 2011;52(3):566–571. doi:10. 11.94/jlr.P011668
  5. Dobiášová M, Frohlich J. The plasma parameter log (TG/HDL) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER HDL). Clinical Biochemistry 2001;34:583-588.
  6. Dobiasova M. AIP—atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice. VnitrLek 2006; 52(1):64–71
  7. Balode et al. Serum lipid profile in chronic kidney disease patients on hemodialysis. Indian Journal of Applied Research. Volume :3. Issue : 8. August 2013. (20 – 22).
  8. Rashmi Rekha et al. Unusual dyslipidemia in patients with chronic kidney diseases. Journal of clinical and diagnostic research. Jan 2017. Vol- 11(1). BC 01 – BC 04
  9. Raju et al. A Study of lipid profile and lipid peroxidation in chronic kidney disease with special reference to hemodialysis. Journal of clinical research and bioethics.2013. 4:1
  10. Chijioke et al. Lipid profile in chronic renal failure patients on dialysis. European Journal of Cardiovascular Medicine. Vol 2. Issue–11. 106–109.
  11. Visconti et al. Lipid disorders in patients with renal failure : role in cardiovascular events and progression of chronic kidney disease. Journal of clinical and translational endocrinology. Vol  2016. 8 –14.
  12. Kasper et al.  Harrison s Principles of Internal Medicine. 19th edition

Corresponding Author

Srividhya.S

Assistant Professor, Department of General Medicine, Kanyakumari Government Medical College, Asaripallam