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Category: Volume 06 Issue 10 October 2018
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Title: To Enumerate the Nucleated Red Blood Cells in Neonatal Sepsis as an Early Response Element to Inflammation in Infection

Authors: Dr N. Muthukumaran. D.M (Neonatology), Dr V. Gowri M.D (Physiology)

 DOI: https://dx.doi.org/10.18535/jmscr/v6i10.205

Abstract

Introduction: Neonatal sepsis is a prevalent medical condition among the babies in all the regions of the world. According to WHO report, annually about 2.7 million neonatal deaths occur worldwide, with more than 35% of them being caused by infectious organisms.

Aim: To enumerate the nucleated RBC count in blood samples of neonates with sepsis. The objective was to relate the count of nucleated RBCs as an early response blood element in detecting the inflammation due to sepsis.

Methodology: A Descriptive study of a sample of 155 neonates divided into culture positive, clinical sepsis and no sepsis groups. The Nucleated Red Blood Cells (NRBC) count per 100 White blood cells (WBC) was counted carefully. A repeat peripheral smear was taken 3 days after admission and compared with the previous results.

Results & Discussion: Out of 115 study neonates, only 101 survived and 14 expired with a mortality of 12.17%. Of the expired 14 babies, 10 were blood culture positive. Mean NRBC in the mortality group was17.1 on day 1, while a repeat count on day 3 showed an increase in the number of circulating NRBCs with mean value 23.1. In the group of babies who survived, NRBCs decreased on day 3 and were even undetected in most of them with a mean value of 3.51. Any unexplained normoblastemia is important because it offers invaluable insight into disease processes or progressions that occur in conditions such as systemic infections.

Conclusion: NRBC count is a simple and valuable marker for detecting the earlier diagnosis of neonatal infection.

Keywords:  Nucleated red blood cells, Neonatal sepsis.

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Corresponding Author

Dr Gowri .V

Senior Assistant Professor of Physiology, Institute of Physiology and Experimental Medicine, Madras Medical College, Chennai-3, India

Phone 9443431451, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.