Title: Prevalence of Primary Open-Angle Glaucoma in Diabetics Attending Postgraduate Department of Ophthalmology GMC Srinagar

Authors: Dr Sajad Mohi Ud Din, Dr Saleema Dar, Dr Farooq Runyal, Dr Anshuli Sood

 DOI: https://dx.doi.org/10.18535/jmscr/v6i10.203

Abstract

Background: In 1971 Becker stated “diabetes mellitus occurs more often in patients with primary open angle glaucoma than in non-glaucomatous populations. Armstrong et al reported a prevalence of POAG of 4.1% in the diabetic patients compared with 1.4% in the controls. However a number of studies have not found association between diabetes and POAG

Objectives: 1) To study the hospital based prevalence of POAG among the diabetic patients attending postgraduate department of ophthalmology G.M.C. Srinagar.

 2) To screen all diabetics for glaucoma

Material and Methods: This cross sectional study was conducted on 100 diabetic patients for a period of one & a half year at postgraduate department of ophthalmology G.M.C Srinagar. Diabetic patients above 50 years were selected as per inclusion and exclusion criteria. Detailed history was noted in all the patients and they underwent ophthalmic evaluation and investigation.

Results: The study group consisted of 100 diabetic patients (52 females and 48 males) in the age group of 50 to 86 years with mean age of 62.15±6.48 years. Overall proportion of POAG cases observed was 5%, NTG cases observed were 2%, OH cases observed were 1% and remaining 93% patients were normal. Among POAG patients, bilateral eye involvement was seen in 4 cases while one patient had only right eye involvement. NTG & OH cases had bilateral eye involvement. Statistically no sex predisposition was present (p>0.05). Mean CD ratio of POAG & normal diabetics was respectively 0.680 & 0.400 (p<0.05).  Neuroretinal rim (NRR) thinning, cupping, vascular changes and peripapillary changes were observed in glaucomatous patients. On OCT, mean linear vertical Cup Disc Ratio as well as Cup Disc Area ratio was found significantly higher in POAG & NTG patients than OH & normal patients. On OCT mean RNFL thickness was found significantly less in POAG & NTG patients than in OH & normal patients in all quadrants

Conclusion: It is concluded that there is excess of POAG among diabetics; thereby showing an association between POAG & Diabeties.

References

  1. Stamper RL, Liberman MF, Drake MV (1999) Becker & Shaffer`s Diagnosis and Therapy of the Glaucomas. (7th Edn), Mosby, St Louis-Missouri.
  2. Klein BE, Klein R, Jensen SC. Open-angle glaucoma and older onset diabetes. The Beaver Dam Eye Study. Ophthalmology 1994; 101:1173-7.
  3. ArmstrongJR, DailvRK, DobsonHL, et al. (1960) The incidence of glaucoma in diabetes mellitus: a comparison with the incidence of glaucoma in the general population. Am J Ophthalmol 50:55–63
  4. Davies PD, Duncan G, Pynsent PB, Arber DL, Lucas VA. Aqueous humour glucose concentration in cataract patients and its effect on the lens. Exp Eye Res. 1984;39:605–609.
  5. Nielsen NV. The prevalence of glaucoma and ocular hypertension in type I and 2 diabetes mellitus: an epidemiological study of diabetes mellitus on the island of Falster, Denmark. Acta Ophthalmol 1983:6l:662–72
  6. George Ronnie, Ramesh Sathyamangalam Ve, Lokapavani Velumuri, Rashima Asokan, Lingam Vijaya;Importance of population based studies;Indian Journal of Ophthalmology,2011,59,7 ,11-18
  7. Anhchuong Le et al. studied ‘Risk Factors Associated with the Incidence of Open-Angle Glaucoma: The Visual Impairment Project’; Investigative Ophthalmology & Visual Science, September 2003, Vol. 44, No. 9(IOVS 2003; 44:3783–3789).
  8. Anand Palimkar, R Khandekar, V Venkataraman; Prevalence and distribution of glaucoma in central India (Glaucoma Survey - 2001). Indian J Ophthalmol 2008;56:57-62.
  9. Naila Ali, Syed Ali Wajid, Nasir Saeed, Muhammad Daud Khan, The Relative Frequency and Risk Factors of Primary Open Angle Glaucoma and Angle Closure Glaucoma Pak J Ophthalmol 2007, Vol. 23 No. 3.
  10. Klein BE, Klein R, Sponsel WE, Franke T, Cantor LB, Martone J, Menage MJ. Prevalence of glaucoma. The Beaver Dam Eye Study. Ophthalmology 1992;99:1499-1504.
  11. Kampougeris G, Spyropoulos D, Mitropoulou A Peripapillary retinal nerve fibre layer thickness measurement with SD-OCT in normal and glaucomatous eyes: distribution and correlation with age. Int J Ophthalmology. 2013;6(5):662-665
  12. Maria Pomorska et al Application of optical coherence tomography in glaucoma suspect eyes. Clin Exp Optom 2012; 95: 1: 78–88.

Corresponding Author

Dr Sajad Mohi Ud Din

GMC Srinagar, India